Comparison of three methods to measure absolute cerebral hemoglobin concentration in neonates by near infrared spectrophotometry

Martin Wolf; Kurt von Siebenthal; Matthias Keel; Vera Dietz M.D.; Oskar Baenziger; Hans Ulrich Bucher M.D.

doi:10.1117/1.1463044

1 April 2002 Comparison of three methods to measure absolute cerebral hemoglobin concentration in neonates by near infrared spectrophotometry

Martin Wolf, Kurt von Siebenthal, Matthias Keel, Vera Dietz M.D., Oskar Baenziger, Hans Ulrich Bucher M.D.

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Journal of Biomedical Optics, Vol. 7, Issue 2, (April 2002). https://doi.org/10.1117/1.1463044

Three methods by which to determine absolute total cerebral hemoglobin concentration (tHb in µmol/L) by near-infrared spectrophotometry (NIRS) have evolved: (1) tHbo, requiring oxygenation changes and arterial oxygen saturation measurements as a reference using a relative NIRS algorithm, (2) tHbg, using a geometrical multidistance principle and (3) tHbgo, a combination of both. The aim of this study was to compare the three methods quantitatively. Sixteen clinically stable preterm infants with a mean gestational age of 29.6 (range of 25.1–36.4) weeks, birthweight of 1386 (680–2820) g and a postnatal age of 2.5 (0.5–6) days, who needed supplemental oxygen, were enrolled. The mean6standard deviation tHbg was 150.2 ±41.8 µmol/L (range of 61.6–228.9 µmol/L), the tHbo was 62.1 ±27.2 µmol/L (26.0–110.8 µmol/L) and the tHbgo was 89.3 ±45.6 µmol/L (26.5–195.9 µmol/L). The correlation coefficient among the three methods were tHbg and tHbgo r=0.736; tHbo and tHbgo r=0.938; tHbg and tHbo r=0.598. A multiple regression with variable selection by Mellow’s C(p) showed, that tHbg was correlated to the birthweight, the postnatal age, the heart rate and the pCO2 (r2=0.588), tHbo and tHbgo were associated with the hemoglobin concentration in the blood, the mean arterial blood pressure and the pCO2 (r2=0.493 and 0.406, respectively). The three methods (tHbg, tHbo, and tHbgo) give systematically different tHb readings and large intersubject variability.

©(2002) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Martin Wolf, Kurt von Siebenthal, Matthias Keel, Vera Dietz M.D., Oskar Baenziger, and Hans Ulrich Bucher M.D. "Comparison of three methods to measure absolute cerebral hemoglobin concentration in neonates by near infrared spectrophotometry," Journal of Biomedical Optics 7(2), (1 April 2002). https://doi.org/10.1117/1.1463044

Published: 1 April 2002

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