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13 March 2024 Correlated vibrational spectroscopies and mass spectrometry imaging of tissues
Shiyue Liu, Maddy Parsons, Vincenzo Abbate, Ka Lung Andrew Chan, Mads S. Bergholt
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Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC128340F (2024) https://doi.org/10.1117/12.3001794
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Triple-negative breast cancer (TNBC) is a challenging disease to treat and there is an unmet need to introduce new tools that offers comprehensive molecular imaging of tissues. Here we introduce an untargeted correlative molecular imaging approach to shed light on TNBC responders and non-responders to chemotherapy. Desorption electrospray ionization (DESI) -mass spectrometry (MS) is an ambient technique for lipidomic/metabolomic imaging. We have developed a comprehensive pipeline to correlate Raman spectroscopy and Fourier-transform infrared spectroscopy imaging with DESI-MSI. This highly complementary transformative imaging tool can enable disruptive research by providing insights in monitoring TNBC progression and identification of new therapeutic targets.
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Shiyue Liu, Maddy Parsons, Vincenzo Abbate, Ka Lung Andrew Chan, and Mads S. Bergholt "Correlated vibrational spectroscopies and mass spectrometry imaging of tissues", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC128340F (13 March 2024); https://doi.org/10.1117/12.3001794
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KEYWORDS
Mass spectrometry
Biological imaging
Tissues
Imaging spectroscopy
Spectroscopy
Vibration
FT-IR spectroscopy
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