Vibrational spectroscopy techniques for the study of cardiorenal syndrome in rat models

Sara Stefani; Martina Alunni Cardinali; Alessandro Cataliotti; Gustavo Jose Justo Silva; Reza Parvan; Marco Paolantoni; Paola Sassi

doi:10.1117/12.2686820

11 August 2023 Vibrational spectroscopy techniques for the study of cardiorenal syndrome in rat models

Sara Stefani, Martina Alunni Cardinali, Alessandro Cataliotti, Gustavo Jose Justo Silva, Reza Parvan, Marco Paolantoni, Paola Sassi

Author Affiliations +

Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 126272D (2023) https://doi.org/10.1117/12.2686820
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Vibrational spectroscopy is a powerful probe of molecular structure and its advantages for biomedical and biophysical research, with a special emphasis on proteins, lipids and nucleic acids, are widely recognized in the literature. It is well-known that infrared and Raman spectroscopic techniques are complementary for the structural analysis of any molecule. Although they differ in selection rules, both techniques are rapid, non-destructive and generally do not need special protocols for sample preparation. Fourier-transform infrared (FTIR) microspectroscopy, in particular, allows for fast biochemical imaging of many biological tissues, however, the application of FTIR for the assessment of heart and kidney lesions induced by cardiovascular diseases has been poorly explored.

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Sara Stefani, Martina Alunni Cardinali, Alessandro Cataliotti, Gustavo Jose Justo Silva, Reza Parvan, Marco Paolantoni, and Paola Sassi "Vibrational spectroscopy techniques for the study of cardiorenal syndrome in rat models", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 126272D (11 August 2023); https://doi.org/10.1117/12.2686820

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