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We present progress towards demonstrating multi-passed stimulated Raman scattering microscopy and multi-passed transmission electron microscopy. A multi-pass microscope interrogates a sample multiple times in a cyclical and deterministic fashion. This can lead to a metrological advantage for imaging weak scatterers. The enhanced sensitivity can yield a significant reduction in damage imparted to biological samples or can reduce image acquisition time. The approach compares favorably with imaging techniques using squeezed or entangled probe states, but avoids the technical complexity associated with the production of such states.
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Mark A. Kasevich, Shaun Burd, Joshua Reynolds, Jerry Yen, "Quantum-optimal bioimaging based on multi-pass reimaging," Proc. SPIE PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics, PC128630F (13 March 2024); https://doi.org/10.1117/12.3005189