Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

Jeeseong Hwang; Hyun-Jin Kim; Paul Lemaillet; Heidrun Wabnitz; Dirk Grosenick; Lin Yang; Thomas Gladytz; David McClatchy III; David Allen; Kimberly Briggman; Brian Pogue

doi:10.1117/12.2263379

15 March 2017 Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy III, David Allen, Kimberly Briggman, Brian Pogue

Author Affiliations +

Proceedings Volume 10056, Design and Quality for Biomedical Technologies X; 1005603 (2017) https://doi.org/10.1117/12.2263379
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We report on a procedure to build and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Controlled inclusion of light scattering titanium dioxide (TiO₂) nanoparticles enables the creation of phantoms having tunable light scattering properties with reduced scattering coefficients consistent across different measurement platforms including an integrating sphere and a time-resolved diffuse optical spectroscopic system. Backscatter confocal microscopy is also used to characterize the shape and distribution of included TiO₂ particles. The double integrating sphere and time-resolved diffuse spectroscopy were used to measure the reduced scattering coefficients of the phantoms. The results across different systems are in good agreement, suggesting that the PDMS/TiO₂ composite is a promising tissue-mimicking material for developing standards useful to validate measurements by different devices for multiplatform and multi-laboratory tests.

Citation Download Citation

Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy III, David Allen, Kimberly Briggman, and Brian Pogue "Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards", Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 1005603 (15 March 2017); https://doi.org/10.1117/12.2263379

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