Anti-hepatocarcinoma effects of resveratrol nanoethosomes against human HepG2 cells

Xiang-Ping Meng; Zhen Zhang; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang

doi:10.1117/12.2251110

20 February 2017 Anti-hepatocarcinoma effects of resveratrol nanoethosomes against human HepG2 cells

Xiang-Ping Meng, Zhen Zhang, Tong-sheng Chen, Yi-fei Wang, Zhi-ping Wang

Proceedings Volume 10065, Biophotonics and Immune Responses XII; 100650T (2017) https://doi.org/10.1117/12.2251110
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Resveratrol (Res) has been widely investigated with its strong anti-tumor activity. However, its low oral bioavailability restricts its wide application. In this study, we prepared resveratrol nanoethosomes (ResN) via ethanol injection method. The in vitro anti-hepatocarcinoma effects of ResN relative to efficacy of bulk Res were evaluated on proliferation and apoptosis of human HepG2 cells. ResN were spherical vesicles and its particle diameter, zeta potential were (115.8 ± 1.3) nm and (-12.8 ± 1.9) mV, respectively. ResN exhibited significant inhibitory effects against human HepG2 cells by MTT assay, and the IC₅₀ value was 49.2 μg/ml (105.4 μg/ml of Res bulk solution). By flow cytometry assay, there was an increase in G2/M phase cells treated with ResN. The results demonstrated ResN could effectively block the G2/M phase of HepG2 cells, which can also enhance the inhibitory effect of Res against HepG2 cells.

Citation Download Citation

Xiang-Ping Meng, Zhen Zhang, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Anti-hepatocarcinoma effects of resveratrol nanoethosomes against human HepG2 cells", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 100650T (20 February 2017); https://doi.org/10.1117/12.2251110

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