Automated assembly of microfluidic "lab-on-a-disc"

M. Berger; T. Müller; T. Voebel; C. Baum; T. Glennon; R. Mishra; D. Kinahan; D. King; J. Ducrée; C. Brecher

doi:10.1117/12.2290348

21 February 2018 Automated assembly of microfluidic "lab-on-a-disc"

M. Berger, T. Müller, T. Voebel, C. Baum, T. Glennon, R. Mishra, D. Kinahan, D. King, J. Ducrée, C. Brecher

Proceedings Volume 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI; 1049109 (2018) https://doi.org/10.1117/12.2290348
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Point-of-care (POC) testing attracts more and more attention in the medical health sector because of their specific property to perform the diagnostic close to the patient. The fast diagnosis right at the hospital or the doctor’s office improves the medical reaction time and the chances for a successful healing process. One of this POC test systems is a “Lab-on-a-Disc” (LoaD) which looks like a compact disc crisscrossed with microfluidic tubes and cavities. The fluid to be analysed is placed in the LoaD and an external device then rotates the LoaD. The cavities inside the LoaD and the centrifugal force ensure a clearly defined sequence of the analysis. Furthermore, we aim for an inexpensive manufacture of the medical product without neglecting its quality and functionality. Therefore, the Fraunhofer IPT works on an assembly cell to implement dissoluble films concisely into the disc. This dissoluble film demonstrates its successful usage as a gate for the fluid, which opens after a predefined moment in the cycle. Furthermore, we investigate to integrate a laser welding process into our gantry system and demonstrate its efficiency with the welding of polymer discs. This procedure is clinically safe because no further laser absorption material is needed in the sealing process, which might pollute the LoaD. Moreover, this process allows the alignment of several discs before the welding and therefore leads to precisely manufactured LoaDs in large quantities. All these methods together enable a fast, costefficient and reliable mass production to bring POC testing among the people.

Conference Presentation

Citation Download Citation

M. Berger, T. Müller, T. Voebel, C. Baum, T. Glennon, R. Mishra, D. Kinahan, D. King, J. Ducrée, and C. Brecher "Automated assembly of microfluidic "lab-on-a-disc"", Proc. SPIE 10491, Microfluidics, BioMEMS, and Medical Microsystems XVI, 1049109 (21 February 2018); https://doi.org/10.1117/12.2290348

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available