A sensor array for detection proteins using lanthanide-doped nanoparticles

Meng Wang; Benqing Zhou; Feifan Zhou; Junle Qu; Wei R. Chen

doi:10.1117/12.2285921

19 February 2018 A sensor array for detection proteins using lanthanide-doped nanoparticles

Meng Wang, Benqing Zhou, Feifan Zhou, Junle Qu, Wei R. Chen

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 104950V (2018) https://doi.org/10.1117/12.2285921
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Lanthanide (Ln³⁺)-doped nanoparticles (NPs) have shown great promise in versatile bioassay. We constructed a supramolecular sensor array by hybridized time-resolved Förster resonance energy transfer (TR-FRET) with the indicator displacement assay (IDA) concept. The sensor array was generated by binding a series of negatively charged indicators on the surface of NaYF_4:Ce/Tb NPs. The sensor array could successfully discriminate 6 model proteins with high accuracy and sensitivity both qualitatively and quantitatively.

Citation Download Citation

Meng Wang, Benqing Zhou, Feifan Zhou, Junle Qu, and Wei R. Chen "A sensor array for detection proteins using lanthanide-doped nanoparticles", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950V (19 February 2018); https://doi.org/10.1117/12.2285921

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