Novel fluorescent oxides provide insight into the dynamics of nanoparticle mediated drug uptake from the gastro-intestinal tract

Waldemar Lipinski; Aleksandra Ozogowska; Jaroslaw Kaszewski; Zdzislaw Gajewski; Marek Godlewski; Michal M. Godlewski

doi:10.1117/12.2306862

17 May 2018 Novel fluorescent oxides provide insight into the dynamics of nanoparticle mediated drug uptake from the gastro-intestinal tract

Waldemar Lipinski, Aleksandra Ozogowska, Jaroslaw Kaszewski, Zdzislaw Gajewski, Marek Godlewski, Michal M. Godlewski

Author Affiliations +

Proceedings Volume 10685, Biophotonics: Photonic Solutions for Better Health Care VI; 106852K (2018) https://doi.org/10.1117/12.2306862
Event: SPIE Photonics Europe, 2018, Strasbourg, France

Abstract

In recent years nanotechnology gathered much attention due to promising applications in biomedicine. Using nanoparticles as drug carriers could allow for more effective and efficient therapy in treating cancer or neurological diseases. This is due to their unique properties such as enhancement of drug bioavailability or the ability to protect the drug from degradation. In this study we performed in vivo (BALB-c mice) and in vitro (Caco-2 cell line) experiments with Y₂O₃:Tb_lectin conjugates as well as pure lectin to characterize the dynamics of nanoparticles mediated drug uptake from gastro-intestinal tract. Mice were given 0.3ml of Y2O3:Tb_lectin conjugates or pure lectin suspension and were sacrificed after 3h, 24h and 1 week (Y₂O₃:Tb_lectin conjugates) or 3h and 24h (pure lectin). Cell cultures were incubated for 24h with increasing concentration (0.001mg/ml; 0.01mg/ml; 0.1mg/ml; 1mg/ml) of Y2O3:Tb_lectin or pure lectin. After analysing gathered data we concluded that our nanoparticles successfully conjugated with lectin and allowed for its transport through physiological barriers. NPs_Lectin conjugates undergo absorption, distribution and redistribution similarly as free nanoparticles do, although it decreased the efficiency of absorption compared to free nanoparticles. Lastly after reaching the tissue conjugates dissolved leading to lectin deposition in the tissue.

Conference Presentation

Citation Download Citation

Waldemar Lipinski, Aleksandra Ozogowska, Jaroslaw Kaszewski, Zdzislaw Gajewski, Marek Godlewski, and Michal M. Godlewski "Novel fluorescent oxides provide insight into the dynamics of nanoparticle mediated drug uptake from the gastro-intestinal tract", Proc. SPIE 10685, Biophotonics: Photonic Solutions for Better Health Care VI, 106852K (17 May 2018); https://doi.org/10.1117/12.2306862

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available