Optical fiber neurosystem for deep-lying brain tumors phototheranostics

Alina S. Sharova; Yuliya S. Maklygina; Igor Romanishkin; Gaukhar M. Yusubalieva; Anastasia V. Ryabova; Vladimir P. Сhekhonin; Victor B. Loschenov

doi:10.1117/12.2312027

28 May 2018 Optical fiber neurosystem for deep-lying brain tumors phototheranostics

Alina S. Sharova, Yuliya S. Maklygina , Igor Romanishkin , Gaukhar M. Yusubalieva, Anastasia V. Ryabova, Vladimir P. Сhekhonin, Victor B. Loschenov

Author Affiliations +

Proceedings Volume 10695, Optical Instrument Science, Technology, and Applications; 106950O (2018) https://doi.org/10.1117/12.2312027
Event: SPIE Optical Systems Design, 2018, Frankfurt, Germany

Abstract

Current paper presents the results of the optical neurosystem research for intracranial implantation targeted on phototheranostics of deep-lying brain tumors. Brain tumors treatment is a complicated multistage process, and currently there is a need for the user-friendly fiber optic toolkit that could allow carrying out multiple diagnostics and therapy of such neoplasms type without additional surgical intervention. The optical neurosystem developed in the framework of this study is based on the scaffold with the internal optical fiber structure placed into the tumor bed and designed for diagnostic and therapeutic laser radiation delivery. Such neurosystem, along with specific photosensitive agent application will provide malignant cells diagnostics by the fluorescent signal and permanent monitoring of processes occurring in the probed area by means of fiber optic probe with emitting and receiving fibers connected with laser source and spectrometer, respectively. The created neurosystem could be used to direct the growth of randomly proliferated deep lying brain tumor cells along the scaffold fibers towards the extracranial surface where malignant cells could be registered, identified and therapeutically affected by photodynamic action. A set of preliminary experiments devoted to spectral-optical evaluation of brain tissue properties was performed. The research of the scaffold and its inner fiber optical structure was carried out on the model samples of brain tissue phantom and in vitro on C6 glioblastoma cell line. Obtained results are being discussed.

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Alina S. Sharova, Yuliya S. Maklygina , Igor Romanishkin , Gaukhar M. Yusubalieva, Anastasia V. Ryabova, Vladimir P. Сhekhonin, and Victor B. Loschenov "Optical fiber neurosystem for deep-lying brain tumors phototheranostics ", Proc. SPIE 10695, Optical Instrument Science, Technology, and Applications, 106950O (28 May 2018); https://doi.org/10.1117/12.2312027

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KEYWORDS

Brain

Tumors

Optical fibers

Fiber optics

Tissues

Diagnostics

Luminescence

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