Metabolism of oral ALA combined small dose HPD in the small rat glioma

Yu Wang; Jing Zhu; Hui-Guo Zhang; Ming Yan; Liping Lu

doi:10.1117/12.639242

11 September 2006 Metabolism of oral ALA combined small dose HPD in the small rat glioma

Yu Wang, Jing Zhu, Hui-Guo Zhang, Ming Yan, Liping Lu

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596714 (2006) https://doi.org/10.1117/12.639242
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective: Research on the metabolism of oral ALA combined small dose HPD in the small rat glioma to find the optimal oral dose and diagnostic time for the ALA-photodynamic diagnosis and therapy of brain glioma. Methods: Measure the fluorescence spectra of tumor in the treatment groups and control group and of brain tissue of no-tumor group with different doses of ALA taken orally combined injected small dose HPD and different time before and after take ALA when irradiated by laser. We analyzed the spectrum of fluorescence of every groups with optical multichannel analyzer (OMA) and compared it each other. Result: The maximum ratio (I_tumor/I_nomal) of fluorescence was obtained at 60mg/kg of ALA taken orally and 6-8h after ALA taken. Conclusion: The optimal oral dose is 60mg/kg of ALA and the optimal measure time is 6-8 hours after ALA taken.

Citation Download Citation

Yu Wang, Jing Zhu, Hui-Guo Zhang, Ming Yan, and Liping Lu "Metabolism of oral ALA combined small dose HPD in the small rat glioma", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596714 (11 September 2006); https://doi.org/10.1117/12.639242

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