Monte Carlo investigation of the effect of skin tissue optical properties on detected Cherenkov emission

Yi Hong Ong; Andrew Q. Li; Timothy C. Zhu

doi:10.1117/12.2509854

7 March 2019 Monte Carlo investigation of the effect of skin tissue optical properties on detected Cherenkov emission

Yi Hong Ong, Andrew Q. Li, Timothy C. Zhu

Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 108621D (2019) https://doi.org/10.1117/12.2509854
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this study, we use Monte Carlo modelling to investigate the effect of tissue optical properties on Cherenkov emission detected from tissue surface. MC simulations are performed for wavelength between 400-1000nm and the values of absorption coefficient at each wavelength are determined based on the molar extinction coefficients of oxy- and deoxy-hemoglobin, with varying total haemoglobin concentration and tissue oxygen saturation of 70%. Tissue reduced scattering coefficient is approximated using μ_s (λ) = Aλ^-0.838. A range of clinically relevant tissue optical properties was investigated, with absorption coefficient between 0.1 and 1 cm^-1 and reduced scattering coefficient between 5 and 40 cm^-1 at 665nm. The angular distribution, depth of origins and the effect of tissue optical properties on Cherenkov emission on tissue surface are evaluated.

Conference Presentation

Citation Download Citation

Yi Hong Ong, Andrew Q. Li, and Timothy C. Zhu "Monte Carlo investigation of the effect of skin tissue optical properties on detected Cherenkov emission", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108621D (7 March 2019); https://doi.org/10.1117/12.2509854

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