BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma

Benqing Zhou; Meng Wang; Feifan Zhou; Jun Song; Junle Qu; Wei R. Chen

doi:10.1117/12.2506097

7 March 2019 BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma

Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu, Wei R. Chen

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790N (2019) https://doi.org/10.1117/12.2506097
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Nanoparticle-based combination therapy may provide an effective therapeutic strategy. Herein, we show that bovine serum albumin (BSA)-bioinspired gold nanorods (GNRs) loaded with immunoadjuvant for combined photothermal therapy (PTT) and immunotherapy for treatment of melanoma. In this work, cetyltrimethylammonium bromide (CTAB) coated GNRs were successively decorated with polyethylene glycol (PEG) and BSA, and loaded with an immunoadjuvant imiquimod (R837). The synthesized mPEGGNRs@ BSA/R837 nanocomplexes could significantly induce immune response in vitro. Furthermore, under near-infrared (NIR) irradiation could effectively kill tumor cells. The nanocomplex-based PTT in combination with immunotherapy may be potentially employed as an effective strategy for the treatment of melanoma and other metastatic cancers.

Citation Download Citation

Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu, and Wei R. Chen "BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790N (7 March 2019); https://doi.org/10.1117/12.2506097

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available