Distinguishes normal and early gastric cancer mucosal structures by multiphoton microscopy

Xueqin Xu; Caihong Sun; Guangxing Wang; Hongxin Lin; Xiaoling Zheng; Shuangmu Zhuo

doi:10.1117/12.2549522

20 December 2019 Distinguishes normal and early gastric cancer mucosal structures by multiphoton microscopy

Xueqin Xu, Caihong Sun, Guangxing Wang, Hongxin Lin, Xiaoling Zheng, Shuangmu Zhuo

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 1120949 (2019) https://doi.org/10.1117/12.2549522
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

The mortality rate of gastric cancer ranks second in the world. The prognosis of early gastric cancer is good, while the prognosis of advanced gastric cancer is poor. Therefore, early diagnosis of gastric cancer is the key to determining the prognosis of patients. Traditional pathological analysis takes a long time, and the results may have some subjectivity and randomness. Therefore, we propose a method for distinguishing normal and early gastric cancer sites by multiphoton microscopy combined with acridine orange rapid staining. The experimental results confirmed that multiphoton microscopy combined with acridine orange staining can effectively describe the normal microstructure of the human gastric mucosa，and these results laid the experimental foundation for the establishment of clinical diagnostic criteria for gastric cancer.

Citation Download Citation

Xueqin Xu, Caihong Sun, Guangxing Wang, Hongxin Lin, Xiaoling Zheng, and Shuangmu Zhuo "Distinguishes normal and early gastric cancer mucosal structures by multiphoton microscopy", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 1120949 (20 December 2019); https://doi.org/10.1117/12.2549522

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KEYWORDS

Cancer

Multiphoton microscopy

Tissues

Second-harmonic generation

Collagen

Endoscopy

Microscopes

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