Method to determine tissue optical properties in anal canal during photodynamic therapy

Andrew C. Li; Yi Hong Ong; Andreea Dimofte; Theresa M. Busch; Timothy C. Zhu

doi:10.1117/12.2546433

24 February 2020 Method to determine tissue optical properties in anal canal during photodynamic therapy

Andrew C. Li, Yi Hong Ong, Andreea Dimofte, Theresa M. Busch, Timothy C. Zhu

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 112200S (2020) https://doi.org/10.1117/12.2546433
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Determination of in-vivo tissue optical properties for anal photodynamic therapy (PDT) is challenging due to the light integrating-sphere effect in an enclosed cylindrical cavity. We developed a model for optical properties determination for anal PDT from measurements of light fluence rate inside a cylindrical cavity submerged in tissue-mimicking liquid phantoms. Measurements are performed in a set of phantoms with known optical properties (μ_a= 0.1-0.9 cm^-1) and (μ_s’ = 6.65-19.95 cm^-1) and the primary and scatter light fluence rates are determined. We developed an analytical expression to relate scatter light fluence rate measured in an enclosed cylindrical geometry to the surrounding tissue optical properties in tissue-simulating liquid phantoms. In addition, the accuracy of determining tissue optical properties using the model was evaluated by comparing the recovered optical properties to the known optical properties of a series of independent test phantoms.

Citation Download Citation

Andrew C. Li, Yi Hong Ong, Andreea Dimofte, Theresa M. Busch, and Timothy C. Zhu "Method to determine tissue optical properties in anal canal during photodynamic therapy", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200S (24 February 2020); https://doi.org/10.1117/12.2546433

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