Multimodal imaging microscope for intraoperative detection of  breast tumors positive margins (Conference Presentation)

Mark T. Scimone; Gopi N. Maguluri; Jesung Park; John Grimble; Savitri Krishnamurthy; Nicusor V. Iftimia

doi:10.1117/12.2542059

9 March 2020 Multimodal imaging microscope for intraoperative detection of breast tumors positive margins (Conference Presentation)

Mark T. Scimone, Gopi N. Maguluri, Jesung Park, John Grimble, Savitri Krishnamurthy, Nicusor V. Iftimia

Author Affiliations +

Proceedings Volume 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII; 112291B (2020) https://doi.org/10.1117/12.2542059
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Identification of positive margins during breast cancer conserving surgery is crucial for successful tumor resection. To address this clinical need, we developed a microscope that combines fluorescent microscopy, optical coherence tomography (OCT), and reflectance confocal microscopy (RCM) to identify the presence of positive tumor margins in surgical specimens. A cancer-targeting fluorescent agent is used to highlight potentially positive margins and guide combined RCM/OCT imaging. Combined RCM/OCT is used to accurately determine the extent of the positive margins, aided by custom image-processing techniques. This instrument has the potential to provide tumor margin guidance in the surgical suite, reducing reliance on lengthy histopathological inquiry and reducing the need for repeated surgery.

Conference Presentation

Citation Download Citation

Mark T. Scimone, Gopi N. Maguluri, Jesung Park, John Grimble, Savitri Krishnamurthy, and Nicusor V. Iftimia "Multimodal imaging microscope for intraoperative detection of breast tumors positive margins (Conference Presentation)", Proc. SPIE 11229, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII, 112291B (9 March 2020); https://doi.org/10.1117/12.2542059

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