Dr. Nicusor V. Iftimia Profile

Dr. Nicusor V. Iftimia

Area Manager/Principal Research Scientist at Physical Sciences Inc

SPIE Involvement:

Conference Program Committee | Author

Publications (64)

Proceedings Article | 13 March 2024 Presentation

Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals

Ge Zhu, John Grimble, Gopi Maguluri, Nicusor Iftimia

Proceedings Volume PC12836, PC128360K (2024) https://doi.org/10.1117/12.3001113

KEYWORDS: Smart sensors, Tissues, Surgery, Tissue optics, Spine, Spinal cord, Sensors, Neck, Machine learning, Interferometry

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Proceedings Article | 13 March 2024 Presentation

Multispectral cellular-level imaging of Aβ in the retina

Mircea Mujat, Ankit Patel, John Grimble, Nicusor Iftimia

Proceedings Volume PC12824, PC128240E (2024) https://doi.org/10.1117/12.3005686

KEYWORDS: Multispectral imaging, Retina, Retinal scanning, In vivo imaging, Alzheimer's disease, Spatial resolution, Retinal diseases, Nervous system, Image resolution, Eye models

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Proceedings Article | 13 March 2024 Presentation + Paper

High-resolution retinal phase gradient imaging using line-scanning laser ophthalmoscopy

Ankit Patel, Nicusor Iftimia, Taeyoon Son, Tobiloba Adejumo, Xincheng Yao, Mircea Mujat

Proceedings Volume 12824, 1282403 (2024) https://doi.org/10.1117/12.3005629

KEYWORDS: Scanning laser ophthalmoscopy, Confocal microscopy, Adaptive optics, Retina, Retinal scanning, Cameras, Light sources and illumination, Visualization, Phase imaging, Eye

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Proceedings Article | 17 March 2023 Presentation

Dual-channel two-photon fluorescence brain imaging using fiber-delivered supercontinuum source

Youbo Zhao, Smrithi Padmakumar, Mark Scimone, Gopi Maguluri, Mansoor Amiji, Nicusor Iftimia

Proceedings Volume PC12365, PC123650E (2023) https://doi.org/10.1117/12.2649900

KEYWORDS: Luminescence, Brain imaging, Supercontinuum sources, Femtosecond phenomena, Brain, Neurons, Neuroimaging, Microscopy, In vivo imaging, Head

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Proceedings Article | 17 March 2023 Presentation

Phase imaging of retinal microstructures with multi-channel AOSLO

Mircea Mujat, Ankit Patel, Nicusor Iftimia

Proceedings Volume PC12360, PC123600W (2023) https://doi.org/10.1117/12.2650877

KEYWORDS: Phase imaging, Visualization, Retinal scanning, Optical fibers, Eye, Wavefronts, Scattering, Retina, Microscopy, Image resolution

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Proceedings Article | 6 March 2023 Presentation

Hand-held OCT probe for transcutaneous use to assess various pathologies in real-time

Nick Iftimia, John Grimble, Gopi Maguluri, Aliana Caron, Rahul Anil Sheth, Sanjay Gupta, Amanda McWaters, Savitri Krishnamurthy

Proceedings Volume PC12373, PC123730C (2023) https://doi.org/10.1117/12.2649157

KEYWORDS: Optical coherence tomography, Pathology, Cancer, Tumor growth modeling, Tissues, Tissue optics, Position sensors, In vivo imaging, Data processing, Birefringence

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Proceedings Article | 6 March 2023 Presentation

Guiding skin cancer therapy with combined confocal-OCT imaging

Nicusor Iftimia, Gopi Maguluri, John Grimble, Mircea Mujat, Aliana Caron, Aditi Sahu, Miguel Cordova, Milind Rajadhyaksha, Christopher Barker

Proceedings Volume PC12368, PC1236807 (2023) https://doi.org/10.1117/12.2649339

KEYWORDS: Skin cancer, Optical coherence tomography, Image resolution, Skin, Tissue optics, Reflectivity, Radiotherapy, Radio optics, Diagnostics, Confocal microscopy

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Proceedings Article | 7 March 2022 Presentation

Noninvasive characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device

Alexander Bang, Jilliana Monnier, Ucalene Harris, Jason Garfinkel, Gennady Rubinstein, Nicusor Iftimia, Melissa Pulitzer, Melissa Murray, Mario Lacouture, Manu Jain

Proceedings Volume PC11934, PC119340B (2022) https://doi.org/10.1117/12.2606921

KEYWORDS: Optical coherence tomography, Imaging devices, Tumors, Breast cancer, Reflectivity, Confocal microscopy, Biopsy, 3D image processing

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Proceedings Article | 5 March 2021 Presentation

Low-cost time-gated imager for intraoperative nerve identification

Mark Scimone, Youbo Zhao, Jason Gunn, Brian Pogue, Nicusor Iftimia

Proceedings Volume 11625, 116250H (2021) https://doi.org/10.1117/12.2582710

KEYWORDS: Nerve, Imaging systems, Luminescence, Visualization, Surgery, Modulation, Light sources, Light emitting diodes, Cameras, CMOS cameras

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Proceedings Article | 5 March 2021 Presentation + Paper

Simultaneous multi-offset imaging of retinal microstructures free of directionality artifacts

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230E (2021) https://doi.org/10.1117/12.2583298

KEYWORDS: Retinal scanning, Optical fibers, Imaging systems, Scanning laser ophthalmoscopy, Scanning laser ophthalmoscopes, Light scattering, Detector development, Capillaries, Blood vessels, Blood

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Proceedings Article | 5 March 2021 Presentation + Paper

Choroidal and retinal hemodynamic imager

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230G (2021) https://doi.org/10.1117/12.2583310

KEYWORDS: Optical coherence tomography, Hemodynamics, Imaging systems, Blood circulation, Visualization, Doppler tomography, Veins, Sensors, Retina, Ophthalmic imaging

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Proceedings Article | 5 March 2021 Presentation

Dual-mode endoscopic system combining OCT and autofluorescence imaging for inner ear hearing loss diagnosis and therapy guidance

Jesung Park, Tao Cheng, Daniel Lee, Gopi Maguluri, John Grimble, Nick Iftimia

Proceedings Volume 11627, 1162705 (2021) https://doi.org/10.1117/12.2582611

KEYWORDS: Endoscopy, Optical coherence tomography, Ear, Auto-fluorescence imaging, Imaging systems, Sensors, Pathology, In vivo imaging, Bone, Animal model studies

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Proceedings Article | 9 March 2020 Presentation

Multimodal imaging microscope for intraoperative detection of breast tumors positive margins (Conference Presentation)

Mark Scimone, Gopi Maguluri, Jesung Park, John Grimble, Savitri Krishnamurthy, Nicusor Iftimia

Proceedings Volume 11229, 112291B (2020) https://doi.org/10.1117/12.2542059

KEYWORDS: Tumors, Microscopes, Multimodal imaging, Breast, Surgery, Confocal microscopy, Optical coherence tomography, Breast cancer, Confocal fluorescent microscopy, Optical microscopy

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Proceedings Article | 9 March 2020 Presentation

Low cost hand scanning OCT probe for biopsy guidance (Conference Presentation)

Gopi Maguluri, Mark Scimone, Jesung Park, John Grimble, Savitri Krishnamurthy, Nicusor Iftimia

Proceedings Volume 11234, 1123415 (2020) https://doi.org/10.1117/12.2549153

KEYWORDS: Biopsy, Optical coherence tomography, Tissues, Tumors, Biosensors

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Proceedings Article | 9 March 2020 Presentation

Automated analysis of tissue heterogeneity based on OCT images for improving personalized cancer therapy effectiveness (Conference Presentation)

Mark Scimone, Gopi Maguluri, Jesung Park, Nicusor Iftimia

Proceedings Volume 11234, 112340I (2020) https://doi.org/10.1117/12.2549156

KEYWORDS: Tissues, Cancer, Optical coherence tomography, Biological research, Biopsy

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Proceedings Article | 6 March 2020 Presentation

Dual-mode endoscopic probe combining OCT and autofluorescence imaging for inner ear hearing loss diagnosis and therapy guidance (Conference Presentation)

Jesung Park, Jeffrey Cheng, Daniel Lee, Jeffrey Holt, Hannah Goldberg, Gopi Maguluri, John Grimble, Nicusor Iftimia

Proceedings Volume 11213, 1121303 (2020) https://doi.org/10.1117/12.2542678

KEYWORDS: Ear, Optical coherence tomography, Endoscopy, Auto-fluorescence imaging, In vivo imaging, Magnetic resonance imaging, Pathology, Visualization, Sensors, Bone

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Proceedings Article | 4 March 2019 Presentation

Optical biopsy of vocal folds during phonation using parallel OCT (Conference Presentation)

Gopi Maguluri, Daryush Mehta, James Kobler, Jesung Park, Nicusor Iftimia

Proceedings Volume 10873, 108730E (2019) https://doi.org/10.1117/12.2510479

KEYWORDS: Optical coherence tomography, Biopsy, 3D image processing, Imaging systems, Video, Visualization, Diagnostics, Endoscopy, Real time imaging

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Proceedings Article | 4 March 2019 Presentation

OCT for core biopsy guidance: a rabbit study (Conference Presentation)

Nicusor Iftimia, Gopi Maguluri, Jesung Park, Sharjeel Sabir

Proceedings Volume 10873, 108730F (2019) https://doi.org/10.1117/12.2508135

KEYWORDS: Biopsy, Optical coherence tomography, Tissues, Core needle biopsy, Image processing, Tumor growth modeling, Cancer

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Proceedings Article | 4 March 2019 Presentation

Combined reflectance confocal microscopy-optical coherence tomography for detection and deep margin assessment of basal cell carcinomas: a clinical study (Conference Presentation)

Aditi Sahu, Oriol Yelamos, Nicusor Iftimia, Miguel Cordova, Christi Alessi-Fox, Melissa Gill, Gopi Maguluri, Stephen Dusza, Cristian Navarrete, Salvador Gonzalez, Anthony Rossi, Ashfaq Marghoob, Milind Rajadhyaksha, Chih-Shan Jason Chen

Proceedings Volume 10871, 108710K (2019) https://doi.org/10.1117/12.2510953

KEYWORDS: Optical coherence tomography, Reflectivity, Confocal microscopy, Diagnostics, Skin, Tumors, Biopsy, In vivo imaging, Blood vessels

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SPIE Journal Paper | 22 October 2018 Open Access

Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

Santosh Balakrishnan, Ruofei Bu, Nicusor Iftimia, Hillel Price, Carlton Zdanski, Amy Oldenburg

JBO, Vol. 23, Issue 10, 100501, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.100501

KEYWORDS: Optical coherence tomography, Computed tomography, In vivo imaging, Data acquisition, Endoscopy, Imaging systems, Physical sciences, Range imaging, Video, Tissues

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Proceedings Article | 14 March 2018 Presentation

New advances in RCM-OCT imaging for non-melanoma skin cancer detection and therapy guidance (Conference Presentation)

Nicusor Iftimia, Gopi Maguluri, Jesung Park, William Fox, Milind Rajadhyaksha

Proceedings Volume 10489, 104890S (2018) https://doi.org/10.1117/12.2291031

KEYWORDS: Skin cancer, Skin, Optical coherence tomography, Confocal microscopy, Software development, 3D image processing, Algorithm development, Optical microscopy, Reflectivity, Laser ablation

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SPIE Journal Paper | 11 July 2017 Open Access

Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

Nicusor Iftimia, Oriol Yélamos, Chih-Shan J. Chen, Gopi Maguluri, Miguel Cordova, Aditi Sahu, Jesung Park, William Fox, Christi Alessi-Fox, Milind Rajadhyaksha

JBO, Vol. 22, Issue 07, 076006, (July 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.7.076006

KEYWORDS: Optical coherence tomography, Reflectivity, Confocal microscopy, Skin, Tumors, In vivo imaging, Spectroscopy, 3D image processing, 3D displays

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Proceedings Article | 1 May 2017 Presentation

Real-time assessment of breast surgical margins with fluorescence-guided microscopy (Conference Presentation)

Nicusor Iftimia, Jesung Park, Gopi Maguluri, Savitri Krishnamurthy

Proceedings Volume 10060, 100600D (2017) https://doi.org/10.1117/12.2256512

KEYWORDS: Cancer, Optical coherence tomography, Optical imaging, Breast cancer, Near infrared, Coherence imaging, Tissue optics, Breast, Laser therapeutics, Microscopy

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Proceedings Article | 28 April 2017 Paper

Anatomic optical coherence tomography for dynamic imaging of the upper airway

Ruofei Bu, Santosh Balakrishnan, Nicusor Iftimia, Hillel Price, Carlton Zdanski, Amy Oldenburg

Proceedings Volume 10137, 101371N (2017) https://doi.org/10.1117/12.2255585

KEYWORDS: Image resolution, Optical scanning systems, Video, Optical coherence tomography, Endoscopy, Imaging systems, Laser sources, Signal to noise ratio, In vivo imaging, Computed tomography

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Proceedings Article | 19 April 2017 Presentation

Multimodal optical imager for inner ear hearing loss diagnosis (Conference Presentation)

Jesung Park, Gopi Maguluri, Youbo Zhao, Nicusor Iftimia

Proceedings Volume 10039, 1003906 (2017) https://doi.org/10.1117/12.2253140

KEYWORDS: Single photon, Sensors, Transducers, Pathology, Auto-fluorescence imaging, Visualization, Imaging systems, Optical coherence tomography, Ear, Surgery

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Proceedings Article | 26 April 2016 Presentation

Core needle biopsy guidance based on EMOCT imaging (Conference Presentation)

Nicusor Iftimia, Jesung Park, Gopi Maguluri

Proceedings Volume 9703, 97030H (2016) https://doi.org/10.1117/12.2213845

KEYWORDS: Cancer, Optical coherence tomography, Tissues, Biopsy, Core needle biopsy, Biological research, Real time imaging, Computer programming, Genetics, Tumors

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Proceedings Article | 26 April 2016 Presentation

Detection of breast positive surgical margins with fluorescence-guided microscopy imaging (Conference Presentation)

Nicusor Iftimia, Dorin Preda, Jesung Park, Mitchell Antalek

Proceedings Volume 9696, 96960S (2016) https://doi.org/10.1117/12.2213887

KEYWORDS: Breast, Microscopy, Cancer, Near infrared, Breast cancer, Tissues, Surgery, Laser therapeutics, Visualization, Physical sciences

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Proceedings Article | 26 April 2016 Presentation

OCT-based profiler for automating ocular surface prosthetic fitting (Conference Presentation)

Mircea Mujat, Ankit Patel, Gopi Maguluri, Nicusor Iftimia, Chirag Patel, Josh Agranat, Olga Tomashevskaya, Eugene Bonte, R. Daniel Ferguson

Proceedings Volume 9693, 96930Z (2016) https://doi.org/10.1117/12.2213938

KEYWORDS: Optical coherence tomography, Sclera, Cornea, Eye, 3D metrology, Physical sciences, Contact lenses, Holmium, Current controlled current source

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SPIE Journal Paper | 18 January 2016 Open Access

Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

Nicusor Iftimia, Gary Peterson, Ernest Chang, Gopi Maguluri, William Fox, Milind Rajadhyaksha

JBO, Vol. 21, Issue 01, 016006, (January 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.1.016006

KEYWORDS: Optical coherence tomography, Tumors, Reflectivity, Confocal microscopy, Tissues, Image resolution, Skin, Tomography, Cancer, Skin cancer

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Proceedings Article | 11 March 2015 Paper

High-resolution retinal imaging: enhancement techniques

Mircea Mujat, Ankit Patel, Nicusor Iftimia, James Akula, Anne Fulton, R. Daniel Ferguson

Proceedings Volume 9307, 930703 (2015) https://doi.org/10.1117/12.2082711

KEYWORDS: Image registration, Imaging systems, Linear filtering, Sensors, Retinal scanning, Digital imaging, Detection and tracking algorithms, Channel projecting optics, Convolution, Matrices

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SPIE Journal Paper | 6 November 2014 Open Access

Low coherence interferometry approach for aiding fine needle aspiration biopsies

Ernest Chang, Joseph Gardecki, Martha Pitman, Eric Wilsterman, Ankit Patel, Guillermo Tearney, Nicusor Iftimia

JBO, Vol. 19, Issue 11, 116005, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.116005

KEYWORDS: Tissues, Tumors, Biopsy, Tissue optics, Interferometry, Fine needle aspiration, Cell biology, Breast, Diagnostics, Optical coherence tomography

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SPIE Journal Paper | 1 May 2014 Open Access

Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study

Dan Savastru, Ernest Chang, Sorin Miclos, Martha Pitman, Ankit Patel, Nicusor Iftimia

JBO, Vol. 19, Issue 05, 056001, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.056001

KEYWORDS: Optical coherence tomography, Tissues, Cancer, Coherence imaging, Breast, Tumors, Tissue optics, Natural surfaces, Breast cancer, Reflectivity

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Proceedings Article | 3 March 2014 Paper

Compact adaptive optics line scanning retinal imager; closer to the clinic

Mircea Mujat, Ankit Patel, Nicusor Iftimia, R. Daniel Ferguson

Proceedings Volume 8930, 89301B (2014) https://doi.org/10.1117/12.2040261

KEYWORDS: Adaptive optics, Imaging systems, Optical coherence tomography, Confocal microscopy, Scanning laser ophthalmoscopy, Cones, Image resolution, Eye, Head, Retinal scanning

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Proceedings Article | 27 September 2013 Paper

Mueller matrix microscopy

Mircea Mujat, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 8873, 88730E (2013) https://doi.org/10.1117/12.2024962

KEYWORDS: Polarization, Microscopes, Optical components, Wave plates, Polarizers, Polarimetry, Microscopy, Refractive index, Birefringence, Dichroic materials

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Proceedings Article | 20 March 2013 Paper

Design of a swept-source, anatomical OCT system for pediatric bronchoscopy

Kushal Wijesundara, Nicusor Iftimia, Amy Oldenburg

Proceedings Volume 8571, 85713K (2013) https://doi.org/10.1117/12.2004226

KEYWORDS: Optical coherence tomography, Imaging systems, Signal to noise ratio, Bronchoscopy, Coherence (optics), Mirrors, Electroluminescence, Fiber optics, Interferometers, Range imaging

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Proceedings Article | 16 February 2011 Paper

Towards real-time wavefront sensorless adaptive optics using a graphical processing unit (GPU) in a line scanning system

David Biss, Ankit Patel, R. Daniel Ferguson, Mircea Mujat, Nicusor Iftimia, Daniel Hammer

Proceedings Volume 7885, 788516 (2011) https://doi.org/10.1117/12.876645

KEYWORDS: Adaptive optics, Sensors, Mirrors, Wavefronts, Imaging systems, Image sensors, Wavefront sensors, Eye, Graphics processing units, Eye models

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Proceedings Article | 16 February 2011 Paper

Advanced capabilities of the multimodal adaptive optics imager

Daniel Hammer, R. Ferguson, Mircea Mujat, David Biss, Nicusor Iftimia, Ankit Patel, Emily Plumb, Melanie Campbell, Jennifer Norris, Alfredo Dubra, Toco Chui, James Akula, Anne Fulton

Proceedings Volume 7885, 78850A (2011) https://doi.org/10.1117/12.876579

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Adaptive optics, Imaging systems, Raster graphics, Video, Multichannel imaging systems, Image registration, Scanners, Doppler effect

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Proceedings Article | 3 March 2010 Paper

Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, Niyom Lue, R. Daniel Ferguson

Proceedings Volume 7550, 755011 (2010) https://doi.org/10.1117/12.846583

KEYWORDS: Adaptive optics, Optical coherence tomography, Scanning laser ophthalmoscopy, Imaging systems, Eye, Eye models, Point spread functions, Retina, Human subjects, Algorithm development

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We developed a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP). The development represents the first ever high performance AO system constructed that combines AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. The SSOCT channel operates at a wavelength of 1 μm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. The system is designed to operate on a broad clinical population with a dual deformable mirror (DM) configuration that allows simultaneous low- and high-order aberration correction. The system also includes a wide field line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation; an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of rotational eye motion; and a high-resolution LCD-based fixation target for presentation to the subject of stimuli and other visual cues. The system was tested in a limited number of human subjects without retinal disease for performance optimization and validation. The system was able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 μm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve targets deep into the choroid. In addition to instrument hardware development, analysis algorithms were developed for efficient information extraction from clinical imaging sessions, with functionality including automated image registration, photoreceptor counting, strip and montage stitching, and segmentation. The system provides clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

SPIE Journal Paper | 1 May 2009 Open Access

Automated algorithm for breast tissue differentiation in optical coherence tomography

Mircea Mujat, Robert Ferguson, Daniel Hammer, Christopher Gittins, Nicusor Iftimia

JBO, Vol. 14, Issue 03, 034040, (May 2009) https://doi.org/10.1117/12.10.1117/1.3156821

KEYWORDS: Tissues, Optical coherence tomography, Tissue optics, Tumors, Biopsy, Breast, Reflectivity, Diagnostics, Coherence imaging, Image processing

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Proceedings Article | 20 February 2009 Paper

Swept-source parallel OCT

Mircea Mujat, Nicusor Iftimia, R. Daniel Ferguson, Daniel Hammer

Proceedings Volume 7168, 71681E (2009) https://doi.org/10.1117/12.809915

KEYWORDS: Optical coherence tomography, Sensors, Image processing, Mirrors, Tissues, Charge-coupled devices, Cameras, Reflectivity, Spectroscopy, Data acquisition

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Proceedings Article | 18 February 2009 Paper

Multimodal scanning laser ophthalmoscopy for image guided treatment of age-related macular degeneration

Daniel Hammer, R. Ferguson, Ankit Patel, Nicusor Iftimia, Mircea Mujat, Deeba Husain

Proceedings Volume 7163, 71631C (2009) https://doi.org/10.1117/12.810050

KEYWORDS: Photodynamic therapy, Angiography, Imaging systems, Eye, Electronics, Confocal microscopy, Scanning laser ophthalmoscopy, Sensors, Head, Video

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Proceedings Article | 18 February 2009 Paper

Compact adaptive optics line scanning laser ophthalmoscope

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, R. Ferguson

Proceedings Volume 7163, 71630J (2009) https://doi.org/10.1117/12.810445

KEYWORDS: Adaptive optics, Cones, Imaging systems, Sensors, Wavefronts, Mirrors, Eye, Retina, Scanning laser ophthalmoscopes, Capillaries

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SPIE Journal Paper | 1 January 2008 Open Access

Automated algorithm for differentiation of human breast tissue using low coherence interferometry for fine needle aspiration biopsy guidance

Brian Goldberg, Nicusor Iftimia, Jason Bressner, Martha Pitman, Elkan Halpern, Brett Bouma, Guillermo Tearney

JBO, Vol. 13, Issue 01, 014014, (January 2008) https://doi.org/10.1117/12.10.1117/1.2837433

KEYWORDS: Tissues, Breast, Tissue optics, Spatial frequencies, Fine needle aspiration, Biopsy, Scattering, Statistical modeling, Interferometry, Algorithm development

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Proceedings Article | 5 March 2007 Paper

High resolution retinal imaging with a compact adaptive optics spectral domain optical coherence tomography system

Daniel Hammer, Nicusor Iftimia, Chad Bigelow, Teoman Ustun, Benjamin Bloom, R. Daniel Ferguson, Stephen Burns

Proceedings Volume 6426, 64261Q (2007) https://doi.org/10.1117/12.703164

KEYWORDS: Adaptive optics, Optical coherence tomography, Scanning laser ophthalmoscopy, Image resolution, Imaging systems, Wavefronts, Eye, Spectral resolution, Raster graphics, Retinal scanning

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Proceedings Article | 10 February 2007 Paper

Three-dimensional tracker for spectral domain optical coherence tomography

Daniel Hammer, Nicusor Iftimia, Chad Bigelow, Teoman Ustun, Benjamin Bloom, R. Daniel Ferguson, Thomas Milner

Proceedings Volume 6429, 642913 (2007) https://doi.org/10.1117/12.704663

KEYWORDS: Optical coherence tomography, Image processing, Imaging systems, Autoregressive models, 3D image processing, Eye, Sensors, Tissues, Optical tracking, Interferometers

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Proceedings Article | 9 February 2007 Paper

Hybrid LSLO/SDOCT retinal imager

Nicusor Iftimia, Daniel Hammer, Chad Bigelow, Teoman Ustun, Andrew Burbo, Johannes de Boer, R. Daniel Ferguson

Proceedings Volume 6426, 642602 (2007) https://doi.org/10.1117/12.701713

KEYWORDS: Optical coherence tomography, Imaging systems, Sensors, Cameras, Data acquisition, Scanners, Light sources, Eye, Raster graphics, Control systems

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SPIE Journal Paper | 1 July 2006 Open Access

Line-scanning laser ophthalmoscope

Daniel Hammer, R. Daniel Ferguson, Teoman Ustun, Chad Bigelow, Nicusor Iftimia, Robert Webb

JBO, Vol. 11, Issue 04, 041126, (July 2006) https://doi.org/10.1117/12.10.1117/1.2335470

KEYWORDS: Scanning laser ophthalmoscopy, Confocal microscopy, Sensors, Cameras, Retina, Eye, Electronics, Point spread functions, Optical components, Glasses

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Proceedings Article | 7 March 2006 Paper

Tracking adaptive optics scanning laser ophthalmoscope

R. Daniel Ferguson, Daniel Hammer, Chad Bigelow, Nicusor Iftimia, Teoman Ustun, Stephen Burns, Ann Elsner, David Williams

Proceedings Volume 6138, 613810 (2006) https://doi.org/10.1117/12.649332

KEYWORDS: Adaptive optics, Eye, Mirrors, Scanning laser ophthalmoscopy, Imaging systems, Cones, Optical tracking, Raster graphics, Scanning laser ophthalmoscopes, Digital signal processing

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Proceedings Article | 7 March 2006 Paper

Precision targeting with a tracking adaptive optics scanning laser ophthalmoscope

Daniel Hammer, R. Daniel Ferguson, Chad Bigelow, Nicusor Iftimia, Teoman Ustun, Gary Noojin, David Stolarski, Harvey Hodnett, Michelle Imholte, Semih Kumru, Michelle McCall, Cynthia Toth, Benjamin Rockwell

Proceedings Volume 6138, 613811 (2006) https://doi.org/10.1117/12.647477

KEYWORDS: Adaptive optics, Scanning laser ophthalmoscopy, Eye, Imaging systems, Mirrors, Retina, Cameras, Cones, Deformable mirrors, Raster graphics

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Proceedings Article | 25 February 2006 Paper

Noninvasive monitoring of blood composition

Nicusor Iftimia, Daniel Hammer, David Rosen, Chad Bigelow, R. Daniel Ferguson

Proceedings Volume 6080, 608002 (2006) https://doi.org/10.1117/12.647045

KEYWORDS: Blood, Reflectivity, Eye, Scattering, Interferometers, Interferometry, Signal processing, Spectroscopy, Motion measurement, Light sources

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Proceedings Article | 18 April 2005 Paper

Dual OCT-SLO imager with 3D tracker

Daniel Hammer, Teoman Ustun, Nick Iftimia, John Magill, R. Daniel Ferguson

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.592762

KEYWORDS: Optical coherence tomography, Signal detection, Scanning laser ophthalmoscopy, Imaging systems, Optical tracking, Signal processing, Bragg cells, Confocal microscopy, 3D image processing, Image resolution

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Proceedings Article | 13 April 2005 Paper

Three-dimensional retinal maps with tracking optical coherence tomography (TOCT)

R. Daniel Ferguson, Daniel Hammer, Nicusor Iftimia, Karim Slaoui, Gadi Wollstein, Hiroshi Ishikawa, Michelle Gabriele, Joel Schuman

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.591764

KEYWORDS: Optical coherence tomography, Optical tracking, Eye, Composites, Mirrors, Imaging systems, Head, 3D acquisition, Signal processing, Image registration

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SPIE Journal Paper | 1 April 2003 Open Access

Speckle reduction in optical coherence tomography by "path length encoded" angular compounding

Nicusor Iftimia, Brett Bouma, Guillermo Tearney

JBO, Vol. 8, Issue 02, (April 2003) https://doi.org/10.1117/12.10.1117/1.1559060

KEYWORDS: Optical coherence tomography, Speckle, Signal to noise ratio, Glasses, Tissues, Optical components, Tissue optics, Computer programming, Objectives, Endoscopes

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SPIE Journal Paper | 1 January 2002 Open Access

Three-dimensional diffuse optical tomography of bones and joints

Yong Xu, Nicusor Iftimia, Huabei Jiang, L. Key, Marcy Bolster

JBO, Vol. 7, Issue 01, (January 2002) https://doi.org/10.1117/12.10.1117/1.1427336

KEYWORDS: Bone, Absorption, 3D image processing, In vivo imaging, Diffuse optical tomography, In vitro testing, 3D metrology, Tissues, Optical properties, Solids

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Proceedings Article | 29 June 2001 Paper

Continuous-wave-based optical imaging of breast: a pilot clinical study

Nicusor Iftimia, Yong Xu, Ye Yang, Julie Eggert, Karin Klove, Lisa Baron, Thomas Pope, Huabei Jiang

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434520

KEYWORDS: Tumors, Breast, Scattering, Mammography, Cancer, Optical imaging, X-rays, Tissue optics, Absorption, Ultrasonography

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Proceedings Article | 29 June 2001 Paper

Three-dimensional optical image reconstruction from phantom and clinical data

Yong Xu, Nicusor Iftimia, Huabei Jiang

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434528

KEYWORDS: 3D image processing, Reconstruction algorithms, 3D image reconstruction, Tumors, Optical properties, Tissues, Image restoration, In vivo imaging, 3D modeling, Diffusion

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Proceedings Article | 29 June 2001 Paper

Frequency-domain fluorescent diffusion tomography of turbid media and in-vivo tissues

Ye Yang, Nicusor Iftimia, Yong Xu, Huabei Jiang

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434529

KEYWORDS: Tissues, Luminescence, Tumors, Diffusion, In vivo imaging, Tomography, Absorption, Scattering media, Reconstruction algorithms, Scattering

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Proceedings Article | 2 July 1998 Paper

Verifying model for statistical hypothesis in detection of noncoherent radiation

Vasile Babin, Simion Ersen, Adrian Moldovan, Nicusor Iftimia

Proceedings Volume 3405, (1998) https://doi.org/10.1117/12.312677

KEYWORDS: Holmium, Statistical modeling, Signal detection, Photons, Signal to noise ratio, Statistical analysis, Space operations, Correlation function, Interference (communication), Quantum optics

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Proceedings Article | 1 June 1998 Paper

CO2 rangefinder and velocimeter system

Nicusor Iftimia, Ileana Iftimia, Emil Cretu, G. Bozeanu

Proceedings Volume 3411, (1998) https://doi.org/10.1117/12.307688

KEYWORDS: Modulation, Heterodyning, Carbon dioxide, Polarization, Oscillators, Solids, Carbon dioxide lasers, Receivers, Modulators, Calibration

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Proceedings Article | 22 December 1997 Paper

CO2 heterodyne remote sensing system

Nicusor Iftimia, Emil Cretu, Ileana Iftimia, Ioan Spanulescu, N. Baltateanu

Proceedings Volume 3218, (1997) https://doi.org/10.1117/12.295650

KEYWORDS: Heterodyning, Remote sensing, Sensing systems, Carbon dioxide, Doppler effect, LIDAR

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Proceedings Article | 23 August 1996 Paper

Measurement of parasite Doppler effect in radar systems using laser heterodyning techniques

Nicusor Iftimia, Mircea Mujat, Virgil Vasiliu, Ileana Iftimia

Proceedings Volume 2868, (1996) https://doi.org/10.1117/12.248658

KEYWORDS: Heterodyning, Doppler effect, Radar, Laser systems engineering, Helium neon lasers, Distance measurement, Antennas, Signal processing, Sensors, Space telescopes

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Proceedings Article | 22 April 1996 Paper

State of the art in CO2 laser Doppler systems at the Institute of Optoelectronics in Romania

Nicusor Iftimia, Teodor Necsoiu, Vasile Babin, Simion Ersen, Adrian Moldovan, Ioan Spanulescu, Marek Strzelec, Zbigniew Puzewicz, Miroslaw Kopica

Proceedings Volume 2773, (1996) https://doi.org/10.1117/12.238518

KEYWORDS: Doppler effect, Sensors, Carbon dioxide lasers, Laser systems engineering, Heterodyning, Signal detection, Oscillators, Optoelectronics, Telescopes, Signal to noise ratio

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Proceedings Article | 8 March 1995 Paper

Comparison between the theoretical and experimental signal-to-noise ratio in optical-heterodyne detection

Nicusor Iftimia, Marek Strzelec, Ioan Spanulescu, Simion Ersen, Vasile Babin, Adrian Moldovan

Proceedings Volume 2461, (1995) https://doi.org/10.1117/12.203599

KEYWORDS: Signal to noise ratio, Sensors, Heterodyning, Oscillators, Quantum efficiency, Signal detection, Receivers, Modulators, Thermal effects, Interference (communication)

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Proceedings Article | 8 June 1994 Paper

Active remote sensing using heterodyne technique

Nicusor Iftimia, Miroslaw Kopica, Ioan Spanulescu, Marek Strzelec

Proceedings Volume 2120, (1994) https://doi.org/10.1117/12.177684

KEYWORDS: Sensors, Signal to noise ratio, Heterodyning, Modulators, Signal detection, Oscillators, Prisms, Polarization, Carbon dioxide lasers, Laser beam propagation

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