Laser-patterned lateral-flow devices with multiple flow-paths for semi-quantitative measurement of the inflammatory biomarker, C-reactive protein (Conference Presentation)

Alice Iles; Peijun J. W. He; Ioannis N. Katis; Panagiotis Galanis; Anto J. Kumar; Jessica L. Teeling; Clive Holmes; Jay Amin; Robert W. Eason; Collin L. Sones

doi:10.1117/12.2542692

9 March 2020 Laser-patterned lateral-flow devices with multiple flow-paths for semi-quantitative measurement of the inflammatory biomarker, C-reactive protein (Conference Presentation)

Alice Iles, Peijun J. W. He, Ioannis N. Katis, Panagiotis Galanis, Anto J. Kumar, Jessica L. Teeling, Clive Holmes, Jay Amin, Robert W. Eason, Collin L. Sones

Author Affiliations +

Proceedings Volume 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII; 1123507 (2020) https://doi.org/10.1117/12.2542692
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We report a novel solution for semi-quantitative detection of C-reactive protein (CRP), a common inflammatory marker, using a multi-path lateral-flow device (LFD) fabricated via the precise partitioning of the single flow-path of a standard LFD using a laser direct-write technique. The multiple isolated flow-paths allow detection of different concentrations by individually setting different cut-off levels. The semi-quantitative readout is observed via simple appearance/absence of test lines without the need for a reader or further analyses. We have successfully demonstrated the use of these multi-path LFDs for semi-quantitative detection of CRP and will present validation in human samples.

Conference Presentation

Citation Download Citation

Alice Iles, Peijun J. W. He, Ioannis N. Katis, Panagiotis Galanis, Anto J. Kumar, Jessica L. Teeling, Clive Holmes, Jay Amin, Robert W. Eason, and Collin L. Sones "Laser-patterned lateral-flow devices with multiple flow-paths for semi-quantitative measurement of the inflammatory biomarker, C-reactive protein (Conference Presentation)", Proc. SPIE 11235, Microfluidics, BioMEMS, and Medical Microsystems XVIII, 1123507 (9 March 2020); https://doi.org/10.1117/12.2542692

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KEYWORDS

Proteins

Point-of-care devices

Blood

Diagnostics

Optical lithography

Visualization

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