Rapid fiber-optic Raman spectroscopy: immediate medical diagnosis in gastrointestinal tracts (Conference Presentation)

Zhiwei Huang

doi:10.1117/12.2551484

10 March 2020 Rapid fiber-optic Raman spectroscopy: immediate medical diagnosis in gastrointestinal tracts (Conference Presentation)

Zhiwei Huang

Author Affiliations +

Proceedings Volume 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine; 112521F (2020) https://doi.org/10.1117/12.2551484
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Gastrointestinal (GI) cancer is the second most commonly diagnosed cancer. Early cancer identification is critical to reducing mortality rates of GI patients. Conventional white-light endoscope, however, suffers from poor diagnostic accuracy of GI cancer during endoscopic examination. Raman spectroscopy represents a unique optical vibrational technique capable of harvesting biomolecular information in tissue with potential for tissue histopathological assessments. In this work, we report the development of a novel simultaneous fingerprint (FP) and high wavenumber (HW) fiber-optic Raman spectroscopy technique as well as its clinical applications for improving real-time in vivo diagnosis of GI cancer at endoscopy. We have demonstrated the diagnostic accuracy of >90% for GI cancer and precancer detection with FP/HW Raman spectroscopy. The rapid fiber-optic Raman spectroscopy also allows the

Conference Presentation

Citation Download Citation

Zhiwei Huang "Rapid fiber-optic Raman spectroscopy: immediate medical diagnosis in gastrointestinal tracts (Conference Presentation)", Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112521F (10 March 2020); https://doi.org/10.1117/12.2551484

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available