Prof. Zhiwei Huang Profile

Prof. Zhiwei Huang

Associate Professor at National Univ of Singapore

SPIE Involvement:

Conference Chair | Conference Program Committee | Editor | Author | Special Event Speaker

Area of Expertise:

Biomedical Optics , Raman spectroscopy , Nonlinear optical microscopy , Biophotonics , Coherent Raman scattering microscopy , Optical diagnosis of precancer and cancer at endoscopy

Websites:

Personal Website

Publications (95)

Proceedings Article | 13 March 2024 Presentation

Fiberoptic Raman endoscopy enables intraoperative, real-time, in vivo bladder cancer diagnosis

Chi Shu, Carmen Ka Man Yu, Chang Liu, Bocheng Qiu, Zhiwei Huang, Arshvin Kesavan, Edmund Chiong

Proceedings Volume PC12839, PC128390A (2024) https://doi.org/10.1117/12.3008510

KEYWORDS: Raman spectroscopy, Endoscopy, Bladder cancer, Tissues, Fiber optics, Cancer, Tumor growth modeling, Bladder, Biomolecules, Tumors

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Proceedings Article | 13 March 2024 Presentation

Label-free monitoring of microplastics and lipid metabolism in live zebrafish with hyperspectral stimulated Raman scattering microscopy

Le Xin, Zhiwei Huang

Proceedings Volume PC12839, PC128390L (2024) https://doi.org/10.1117/12.3008490

KEYWORDS: Raman scattering, Mode conditioning cables, Microscopy, Picosecond phenomena, Liver, Biological imaging, Brain, Vibration, Toxicity, Organisms

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Proceedings Article | 13 March 2024 Presentation

Quantitative monitoring of microplastics and lipid metabolism in live zebrafish via hyperspectral stimulated Raman scattering microscopy

Le Xin, Zhiwei Huang

Proceedings Volume PC12855, PC128550M (2024) https://doi.org/10.1117/12.3008492

KEYWORDS: Raman scattering, Mode conditioning cables, Microscopy, Picosecond phenomena, Liver, Biological imaging, Vibration, Toxicity, Stereoscopy, Organisms

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Proceedings Article | 13 March 2024 Presentation

Stimulated Raman scattering tomography enabled by counter-propagating ultraslow Bessel beam pulses for deeper tissue chemical imaging

Shulang Lin, Zhiwei Huang

Proceedings Volume PC12839, PC128390N (2024) https://doi.org/10.1117/12.3008493

KEYWORDS: Imaging spectroscopy, Bessel beams, Tissues, Raman scattering, Tomography, Biological imaging, Stereoscopy, Tissue optics, Spatial light modulators, Polymers

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Proceedings Article | 13 March 2024 Presentation

Stimulated Raman scattering tomography enabled by counter-propagating ultraslow Bessel light bullets for deeper tissue chemical imaging

Shulang Lin, Zhiwei Huang

Proceedings Volume PC12855, PC128550E (2024) https://doi.org/10.1117/12.3008494

KEYWORDS: Bessel beams, Imaging spectroscopy, Tomography, Tissues, Raman scattering, Biological imaging, Stereoscopy, Spatial light modulators, Tissue optics, Polymers

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Proceedings Article | 13 March 2024 Presentation

Multi-needle fiberoptic Raman spectroscopy technique for simultaneous multi-site deep tissue Raman measurements in brain

Zhiwei Huang, Chi Shu, Bocheng Qiu

Proceedings Volume PC12839, PC128390E (2024) https://doi.org/10.1117/12.3008485

KEYWORDS: Raman spectroscopy, Brain, Fiber optics, Fiber optics tests, Brain tissue, Tissues, Algorithm development, White matter, Thalamus, Spectroscopy

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SPIE Journal Paper | 15 February 2024 Open Access

Stimulated Raman scattering tomography for rapid three-dimensional chemical imaging of cells and tissue

Weiqi Wang, Zhiwei Huang

AP, Vol. 6, Issue 02, 026001, (February 2024) https://doi.org/10.1117/12.10.1117/1.AP.6.2.026001

KEYWORDS: 3D image processing, Tissues, Stereoscopy, Biological imaging, Raman scattering, Tomography, Imaging systems, Imaging spectroscopy, 3D acquisition, Spatial light modulators

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Proceedings Article | 7 March 2022 Presentation

Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements

Chi Shu, Wei Zheng, Zhuo Wang, Changyuan Yu, Zhiwei Huang

Proceedings Volume PC11957, PC119570F (2022) https://doi.org/10.1117/12.2614404

KEYWORDS: Raman spectroscopy, Tissues, Fiber optics, Fiber optics tests, Tissue optics, In vivo imaging, Brain, Biopsy, Algorithm development, Skin

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Proceedings Article | 7 March 2022 Presentation

In vivo fiberoptic Raman spectroscopy enables real-time post-treatment surveying and tumor recurrence detection for nose cancer patients

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, Chweeming Lim

Proceedings Volume PC11954, PC1195409 (2022) https://doi.org/10.1117/12.2607347

KEYWORDS: Raman spectroscopy, Tumors, In vivo imaging, Fiber optics, Nose, Cancer, Tissues, Collagen, Inflammation, Diagnostics

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Proceedings Article | 7 March 2022 Presentation

Real-time recurrent nasopharyngeal carcinoma diagnosis and treatment efficacy follow-up at endoscopy using fiberoptic Raman spectroscopy

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, Chweeming Lim

Proceedings Volume PC11957, PC119570C (2022) https://doi.org/10.1117/12.2607349

KEYWORDS: Raman spectroscopy, Fiber optics, Endoscopy, Tissues, Diagnostics, Collagen, Tumors, Tumor growth modeling, Molecular spectroscopy, Inflammation

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Proceedings Article | 10 March 2020 Presentation

Rapid fiber-optic Raman spectroscopy: immediate medical diagnosis in gastrointestinal tracts (Conference Presentation)

Zhiwei Huang

Proceedings Volume 11252, 112521F (2020) https://doi.org/10.1117/12.2551484

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Proceedings Article | 9 March 2020 Presentation

Deep learning-based fiberoptic Raman spectroscopy improves in vivo diagnosis of nasopharyngeal carcinoma at endoscopy (Conference Presentation)

Chi Shu, Hanshu Yan, Kan Lin, Chwee Ming Lim, Wei Zheng, Jiashi Feng, Zhiwei Huang

Proceedings Volume 11236, 1123604 (2020) https://doi.org/10.1117/12.2543462

KEYWORDS: Raman spectroscopy, Fiber optics, Endoscopy, Diagnostics, Cancer, Neural networks, Tumor growth modeling, Tissues, Chemometrics, Surveillance

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Proceedings Article | 9 March 2020 Presentation

Enhancing in vivo nose cancer detection with rapid fiberoptic Raman and deep learning techniques (Conference Presentation)

Chi Shu, Hanshu Yan, Kan Lin, Chwee Ming Lim, Wei Zheng, Jiashi Feng, Zhiwei Huang

Proceedings Volume 11234, 112340O (2020) https://doi.org/10.1117/12.2545618

KEYWORDS: Raman spectroscopy, In vivo imaging, Fiber optics, Nose, Cancer, Diagnostics, Neural networks, Performance modeling, Tumor growth modeling, Tissues

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Proceedings Article | 14 March 2016 Paper

Hyperspectral stimulated Raman scattering and multiphoton imaging for digital pathology of colonic disease

Zi Wang, Wei Zheng, Jian Lin, Zhiwei Huang

Proceedings Volume 9712, 97120G (2016) https://doi.org/10.1117/12.2212749

KEYWORDS: Raman scattering, Multiphoton microscopy, Microscopy, Second-harmonic generation, Optical microscopy, Luminescence, Independent component analysis, Image analysis, Proteins, Multiphoton fluorescence microscopy, Tissues, Cancer, Raman spectroscopy, Pathology, Colon, Imaging systems, Optical parametric oscillators

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Proceedings Article | 14 March 2016 Paper

High-resolution stimulated Raman scattering microscopy by focal-field modulation

Jian Lin, Wei Zheng, Zhiwei Huang

Proceedings Volume 9712, 971220 (2016) https://doi.org/10.1117/12.2211978

KEYWORDS: Molecules, Microscopy, Raman scattering, Polarization, Light scattering, Raman spectroscopy, Tissues, CARS tomography, Spectroscopy, Phase modulation, Modulation, Phase shift keying, Spatial resolution, Polymethylmethacrylate, Spatial light modulators, Medical research

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Proceedings Article | 7 March 2016 Paper

Diagnosis potential of near infrared Mueller Matrix imaging for colonic adenocarcinoma

Jianfeng Wang, Wei Zheng, Kan Lin, Zhiwei Huang

Proceedings Volume 9698, 96980X (2016) https://doi.org/10.1117/12.2212074

KEYWORDS: Colon, Near infrared, Tissues, Imaging systems, Wave plates, Mueller matrices, Medical imaging, Imaging devices, Polarizers, Diagnostics, Ultraviolet radiation, Biomedical optics

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Proceedings Article | 7 March 2016 Paper

Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study

Jianfeng Wang, Kan Lin, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Proceedings Volume 9704, 97040D (2016) https://doi.org/10.1117/12.2212067

KEYWORDS: Raman spectroscopy, In vivo imaging, Endoscopy, Diagnostics, Fiber optics, Tissue optics, Optical spectroscopy, Spectroscopy, Tissues, Cancer, Proteins, Medicine

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Proceedings Article | 7 March 2016 Paper

Near-infrared Mueller matrix imaging for colonic cancer detection

Jianfeng Wang, Wei Zheng, Kan Lin, Zhiwei Huang

Proceedings Volume 9703, 970318 (2016) https://doi.org/10.1117/12.2212064

KEYWORDS: Cancer, Tissues, Colon, Imaging systems, Wave plates, Mueller matrices, Near infrared, Polarizers, Ultraviolet radiation, Diagnostics

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Proceedings Article | 7 March 2016 Paper

Dental caries imaging using hyperspectral stimulated Raman scattering microscopy

Zi Wang, Wei Zheng, Lin Jian, Zhiwei Huang

Proceedings Volume 9704, 97040M (2016) https://doi.org/10.1117/12.2213793

KEYWORDS: Imaging systems, Hyperspectral imaging, Raman scattering, Raman spectroscopy, Picosecond phenomena, Optical parametric oscillators, Polarization, Multiphoton microscopy, Imaging spectroscopy, Multiphoton spectroscopy, Dental caries, Teeth, Microscopy, Laser dentistry

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Proceedings Article | 4 March 2016 Paper

Glucose sensing through Fano resonances in mesoscale silica core-gold shell particles arrays

Francesca Pincella, Zhiwei Huang

Proceedings Volume 9715, 97150V (2016) https://doi.org/10.1117/12.2211681

KEYWORDS: Glucose, Particles, Plasmonic sensors, Gold, Refractive index, Surface plasmons, Optical sensing, Silica, Plasmonics, Blood, Sensors, Nanoparticles

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Proceedings Article | 29 February 2016 Paper

Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, Zhiwei Huang

Proceedings Volume 9689, 96892B (2016) https://doi.org/10.1117/12.2213964

KEYWORDS: Raman spectroscopy, Endoscopy, Tissues, In vivo imaging, Cancer, Proteins, Fiber optics, Diagnostics, Neck, Head

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Proceedings Article | 5 March 2015 Paper

Compact Raman needle probe with fine needle aspiration biopsy for solid tissues

Jianfeng Wang, Wei Zheng, Zhiwei Huang

Proceedings Volume 9317, 931703 (2015) https://doi.org/10.1117/12.2080944

KEYWORDS: Raman spectroscopy, Tissues, Biopsy, Solids, Fine needle aspiration, Tissue optics, Spectroscopy, In vivo imaging, Spectroscopes, Optical fibers

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Proceedings Article | 5 March 2015 Paper

Study of acetowhitening mechanisms in live mammalian cells with label-free subcellular-level multimodal nonlinear optical microscopy

Jian Lin, Sengkhoon Teh, Wei Zheng, Zi Wang, Zhiwei Huang

Proceedings Volume 9329, 93290T (2015) https://doi.org/10.1117/12.2080818

KEYWORDS: Proteins, Microscopy, Optical microscopy, Bandpass filters, Live cell imaging, Optical filters, Scattering, Optical parametric oscillators, Mirrors, Tissues

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Proceedings Article | 5 March 2015 Paper

Simultaneous quadruple modal nonlinear optical imaging for gastric diseases diagnosis and characterization

Zi Wang, Wei Zheng, Jian Lin, Zhiwei Huang

Proceedings Volume 9329, 93291P (2015) https://doi.org/10.1117/12.2080901

KEYWORDS: Second-harmonic generation, Tissues, Mirrors, Optical imaging, Microscopy, Collagen, Imaging systems, Electronic filtering, Optical microscopy, Luminescence

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Proceedings Article | 4 March 2015 Paper

A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach

Kan Lin, Mads Bergholt, Jianfeng Wang, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Proceedings Volume 9313, 93130I (2015) https://doi.org/10.1117/12.2080896

KEYWORDS: Raman spectroscopy, Endoscopy, Tissues, In vivo imaging, Stomach, Proteins, Diagnostics, Medicine, Imaging systems, Fiber optics

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Proceedings Article | 2 March 2015 Paper

Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer

Kan Lin, Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Proceedings Volume 9304, 93040V (2015) https://doi.org/10.1117/12.2080851

KEYWORDS: Raman spectroscopy, Endoscopy, In vivo imaging, Tissue optics, Fiber optics, Proteins, Tissues, Medicine, Diagnostics, Colorectal cancer

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Proceedings Article | 4 March 2014 Paper

Real-time depth-resolved fiber optic Raman endoscopy for in vivo diagnosis of gastric precancer

Mads Bergholt, Wei Zheng, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy So, Zhiwei Huang

Proceedings Volume 8939, 89390M (2014) https://doi.org/10.1117/12.2039552

KEYWORDS: Raman spectroscopy, Endoscopy, In vivo imaging, Fiber optics, Diagnostics, Tissues, Medicine, Biopsy, Algorithm development, Confocal microscopy

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Proceedings Article | 4 March 2014 Paper

Quantitative fiber-optic Raman spectroscopy for tissue Raman measurements

Shiyamala Duraipandian, Mads Bergholt, Wei Zheng, Zhiwei Huang

Proceedings Volume 8939, 89390V (2014) https://doi.org/10.1117/12.2039576

KEYWORDS: Raman spectroscopy, Fiber optics, In vivo imaging, Tissue optics, Tissues, Laser tissue interaction, Fiber optics tests, Laser induced plasma spectroscopy, Sapphire, Biomedical optics

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Proceedings Article | 28 February 2014 Paper

Integrated coherent Raman scattering and multiphoton microscopy for label-free imaging of the dentin in the tooth

Zi Wang, Wei Zheng, Jian Lin, Chin-Ying Hsu, Zhiwei Huang

Proceedings Volume 8948, 89482N (2014) https://doi.org/10.1117/12.2039683

KEYWORDS: Second-harmonic generation, Teeth, Mirrors, Microscopy, Optical filters, Bandpass filters, CARS tomography, Multiphoton microscopy, Optical microscopy, Harmonic generation

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Proceedings Article | 28 February 2014 Paper

Simultaneous stimulated Raman scattering and higher harmonic generation imaging for liver disease diagnosis without labeling

Jian Lin, Zi Wang, Wei Zheng, Zhiwei Huang

Proceedings Volume 8948, 89480V (2014) https://doi.org/10.1117/12.2039456

KEYWORDS: Liver, Second-harmonic generation, Bandpass filters, Tissues, Mirrors, Microscopy, Collagen, Signal detection, Optical filters, Raman scattering

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SPIE Journal Paper | 24 June 2013 Open Access

Near-infrared-excited confocal Raman spectroscopy advances in vivo diagnosis of cervical precancer

Shiyamala Duraipandian, Wei Zheng, Joseph Ng, Jeffrey Low, Arunachalam Ilancheran, Zhiwei Huang

JBO, Vol. 18, Issue 06, 067007, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.067007

KEYWORDS: Raman spectroscopy, Near infrared, Confocal microscopy, Tissues, Atrial fibrillation, In vivo imaging, Diagnostics, Spectroscopy, Tissue optics, Composites

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Proceedings Article | 22 March 2013 Paper

Integrated fingerprint and high wavenumber confocal Raman spectroscopy for in vivo diagnosis of cervical precancer

Shiyamala Duraipandian, Wei Zheng, Joseph Ng, Jeffrey J. Low, A. Ilancheran, Zhiwei Huang

Proceedings Volume 8572, 85720Z (2013) https://doi.org/10.1117/12.2003058

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Tissue optics, Spectroscopy, Diagnostics, Cervix, Confocal microscopy, Proteins, Cancer

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Proceedings Article | 20 March 2013 Paper

Real-time depth-resolved Raman endoscopy for in vivo diagnosis of dysplasia in Barrett's esophagus

Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, Zhiwei Huang

Proceedings Volume 8576, 85760D (2013) https://doi.org/10.1117/12.2003995

KEYWORDS: Raman spectroscopy, Endoscopy, In vivo imaging, Esophagus, Tissues, Diagnostics, Biopsy, Proteins, Algorithm development, Near infrared

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Proceedings Article | 19 March 2013 Paper

Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination

Zhiwei Huang, Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, Asim Shabbir

Proceedings Volume 8577, 85770G (2013) https://doi.org/10.1117/12.2005697

KEYWORDS: Raman spectroscopy, Endoscopy, In vivo imaging, Cancer, Diagnostics, Tissues, Imaging systems, Proteins, Biopsy, Medicine

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SPIE Journal Paper | 28 February 2013 Open Access

Development of a multiplexing fingerprint and high wavenumber Raman spectroscopy technique for real-time in vivo tissue Raman measurements at endoscopy

Mads Sylvest Bergholt, Wei Zheng, Zhiwei Huang

JBO, Vol. 18, Issue 03, 030502, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.030502

KEYWORDS: Raman spectroscopy, Endoscopy, Multiplexing, In vivo imaging, Tissue optics, Charge-coupled devices, Spectral resolution, Tissues, Image segmentation, Laser tissue interaction

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Proceedings Article | 22 February 2013 Paper

Polarization-coded coherent anti-Stokes Raman scattering microscopy for nonresonant background suppression

Jian Lin, Paul Kumar Upputuri, Gong Li, Haifeng Wang, Zhiwei Huang

Proceedings Volume 8588, 858809 (2013) https://doi.org/10.1117/12.2005561

KEYWORDS: CARS tomography, Microscopy, Polarization, Molecules, Signal detection, Microscopes, Multiphoton microscopy, Polarized microscopy, Mirrors, Medical research

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SPIE Journal Paper | 2 August 2012 Open Access

Real-time Raman spectroscopy for in vivo, online gastric cancer diagnosis during clinical endoscopic examination

Shiyamala Duraipandian, Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Jimmy Bok Yan So, Asim Shabbir, Zhiwei Huang

JBO, Vol. 17, Issue 8, 081418, (August 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081418

KEYWORDS: Raman spectroscopy, Cancer, Diagnostics, Endoscopy, In vivo imaging, Spectroscopy, Tissues, Tissue optics, Biomedical optics, Principal component analysis

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Optical spectroscopic techniques including reflectance, fluorescence and Raman spectroscopy have shown promising potential for in vivo precancer and cancer diagnostics in a variety of organs. However, data-analysis has mostly been limited to post-processing and off-line algorithm development. In this work, we develop a fully automated on-line Raman spectral diagnostics framework integrated with a multimodal image-guided Raman technique for real-time in vivo cancer detection at endoscopy. A total of 2748 in vivo gastric tissue spectra (2465 normal and 283 cancer) were acquired from 305 patients recruited to construct a spectral database for diagnostic algorithms development. The novel diagnostic scheme developed implements on-line preprocessing, outlier detection based on principal component analysis statistics (i.e., Hotelling’s T2 and Q-residuals) for tissue Raman spectra verification as well as for organ specific probabilistic diagnostics using different diagnostic algorithms. Free-running optical diagnosis and processing time of < 0.5 s can be achieved, which is critical to realizing real-time in vivo tissue diagnostics during clinical endoscopic examination. The optimized partial least squares-discriminant analysis (PLS-DA) models based on the randomly resampled training database (80% for learning and 20% for testing) provide the diagnostic accuracy of 85.6% [95% confidence interval (CI): 82.9% to 88.2%] [sensitivity of 80.5% (95% CI: 71.4% to 89.6%) and specificity of 86.2% (95% CI: 83.6% to 88.7%)] for the detection of gastric cancer. The PLS-DA algorithms are further applied prospectively on 10 gastric patients at gastroscopy, achieving the predictive accuracy of 80.0% (60/75) [sensitivity of 90.0% (27/30) and specificity of 73.3% (33/45)] for in vivo diagnosis of gastric cancer. The receiver operating characteristics curves further confirmed the efficacy of Raman endoscopy together with PLS-DA algorithms for in vivo prospective diagnosis of gastric cancer. This work successfully moves biomedical Raman spectroscopic technique into real-time, on-line clinical cancer diagnosis, especially in routine endoscopic diagnostic applications.

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SPIE Journal Paper | 27 July 2012 Open Access

Errata: In vivo, real-time, transnasal, image-guided Raman endoscopy: defining spectral properties in the nasopharynx and larynx

Mads Sylvest Bergholt, Kan Lin, Wei Zheng, Zhiwei Huang, David Lau

JBO, Vol. 17, Issue 7, 079804, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.079804

KEYWORDS: In vivo imaging, Raman spectroscopy, Endoscopy, Biomedical optics, Tissues

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SPIE Journal Paper | 9 July 2012 Open Access

In vivo, real-time, transnasal, image-guided Raman endoscopy: defining spectral properties in the nasopharynx and larynx

Mads Sylvest Bergholt, Kan Lin, Wei Zheng, Zhiwei Huang, David Lau

JBO, Vol. 17, Issue 7, 077002, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.077002

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Endoscopy, Head, Neck, Principal component analysis, Diagnostics, Proteins, Cancer

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Proceedings Article | 22 February 2012 Paper

Effect of hormonal variation on in vivo high wavenumber Raman spectra improves cervical precancer detection

Shiyamala Duraipandian, Wei Zheng, Joseph Ng, Jeffrey J. Low, A. Ilancheran, Zhiwei Huang

Proceedings Volume 8214, 82140A (2012) https://doi.org/10.1117/12.906399

KEYWORDS: Raman spectroscopy, Tissues, Cervix, Spectroscopy, Diagnostics, In vivo imaging, Principal component analysis, Molecular spectroscopy, Cancer, Near infrared

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Proceedings Article | 9 February 2012 Paper

An integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique for liver disease diagnosis

Jian Lin, Fake Lu, Wei Zheng, Hanry Yu, Colin Sheppard, Zhiwei Huang

Proceedings Volume 8226, 822625 (2012) https://doi.org/10.1117/12.908200

KEYWORDS: Liver, Tissues, Microscopy, Second-harmonic generation, Collagen, Optical microscopy, CARS tomography, Tissue optics, Multiphoton microscopy, Beam splitters

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Proceedings Article | 2 February 2012 Paper

Radially polarized tip-enhanced near-field coherent anti-Stokes Raman scattering microscopy for bioimaging

Jian Lin, Kenneth Er, Zhiwei Huang

Proceedings Volume 8231, 82310B (2012) https://doi.org/10.1117/12.908476

KEYWORDS: Near field scanning optical microscopy, Microscopy, CARS tomography, Near field, Spatial resolution, Microscopes, Diffraction, Imaging systems, Polarization, Raman spectroscopy

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Proceedings Article | 1 February 2012 Paper

Univariate and multivariate methods for chemical mapping of cervical cancer cells

Shiyamala Duraipandian, Wei Zheng, Zhiwei Huang

Proceedings Volume 8219, 82190A (2012) https://doi.org/10.1117/12.908567

KEYWORDS: Raman spectroscopy, Cervical cancer, Cancer, Microscopy, Proteins, Principal component analysis, Tissues, Micro raman spectroscopy, Visualization, Luminescence

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Proceedings Article | 1 February 2012 Paper

Detection of malignant lesions in vivo in the upper gastrointestinal tract using image-guided Raman endoscopy

Mads Sylvest Bergholt, Wei Zheng, Kan Lin, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, Zhiwei Huang

Proceedings Volume 8219, 82190M (2012) https://doi.org/10.1117/12.908652

KEYWORDS: Raman spectroscopy, Endoscopy, Cancer, In vivo imaging, Tissues, Esophagus, Diagnostics, Proteins, Biopsy, Algorithm development

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SPIE Journal Paper | 1 November 2011 Open Access

Assessment of liver steatosis and fibrosis in rats using integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique

Jian Lin, Fake Lu, Wei Zheng, Zhiwei Huang, Shuoyu Xu, Dean Tai, Hanry Yu

JBO, Vol. 16, Issue 11, 116024, (November 2011) https://doi.org/10.1117/12.10.1117/1.3655353

KEYWORDS: Liver, Tissues, Second-harmonic generation, Collagen, Microscopy, CARS tomography, Tissue optics, Imaging systems, 3D image processing, Surgery

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SPIE Journal Paper | 1 June 2011 Open Access

In vivo diagnosis of colonic precancer and cancer using near-infrared autofluorescence spectroscopy and biochemical modeling

Xiaozhuo Shao, Wei Zheng, Zhiwei Huang

JBO, Vol. 16, Issue 06, 067005, (June 2011) https://doi.org/10.1117/12.10.1117/1.3589099

KEYWORDS: Tissues, Atrial fibrillation, Near infrared, Cancer, In vivo imaging, Spectroscopy, Near infrared spectroscopy, Imaging spectroscopy, Tumor growth modeling, Endoscopy

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SPIE Journal Paper | 1 March 2011 Open Access

Characterizing variability in in vivo Raman spectra of different anatomical locations in the upper gastrointestinal tract toward cancer detection

Mads Bergholt, Wei Zheng, Kan Lin, Zhiwei Huang, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Yan So

JBO, Vol. 16, Issue 03, 037003, (March 2011) https://doi.org/10.1117/12.10.1117/1.3556723

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Endoscopy, Esophagus, Tissue optics, Cancer, Proteins, Collagen, Tumor growth modeling

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Proceedings Article | 23 February 2011 Paper

Multimodal nonlinear optical imaging of obesity-induced liver steatosis and fibrosis

Jian Lin, Fake Lu, Wei Zheng, Dean C. Tai, Hanry Yu, Colin Sheppard, Zhiwei Huang

Proceedings Volume 7903, 79031V (2011) https://doi.org/10.1117/12.873507

KEYWORDS: Liver, Tissues, Microscopy, Collagen, Second-harmonic generation, Optical microscopy, CARS tomography, Multimodal imaging, Nonlinear optics, Optical imaging

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Proceedings Article | 23 February 2011 Paper

High contrast coherent anti-Stokes Raman scattering microscopy using tightly focused cylindrical vector beams

Jian Lin, Fake Lu, Wei Zheng, Zhiwei Huang

Proceedings Volume 7903, 79031F (2011) https://doi.org/10.1117/12.873674

KEYWORDS: Microscopy, CARS tomography, Finite-difference time-domain method, Objectives, Signal detection, Molecules, Medical research, Near field optics, Tissue optics, Near field

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Proceedings Article | 3 January 2011 Paper

Multimodal endoscopic imaging and Raman spectroscopy for improving in vivo diagnosis of gastric malignancies during clinical gastroscopy

Mads Sylvest Bergholt, Wei Zheng, Kan Lin, Khek Yu Ho, Khay Guan Yeoh, Ming Teh, Jimmy Bok Yan So, Zhiwei Huang

Proceedings Volume 7990, 79900A (2011) https://doi.org/10.1117/12.887956

KEYWORDS: Raman spectroscopy, In vivo imaging, Endoscopy, Tissues, Cancer, Imaging systems, Imaging spectroscopy, Multimodal imaging, Proteins, Tissue optics

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SPIE Journal Paper | 1 January 2011 Open Access

Early detection of biomolecular changes in disrupted porcine cartilage using polarized Raman spectroscopy

Natalie Jie Lim, Zaribafzadeh Hamed, Chen Hua Yeow, Casey Chan, Zhiwei Huang

JBO, Vol. 16, Issue 1, 017003, (January 2011) https://doi.org/10.1117/12.10.1117/1.3528006

KEYWORDS: Raman spectroscopy, Cartilage, Collagen, Confocal microscopy, Tissues, Optical fibers, Microscopy, Bone, Polarization, Signal detection

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SPIE Journal Paper | 1 July 2010 Open Access

Integrated autofluorescence endoscopic imaging and point-wise spectroscopy for real-time in vivo tissue measurements

Kan Lin, Wei Zheng, Zhiwei Huang

JBO, Vol. 15, Issue 04, 040507, (July 2010) https://doi.org/10.1117/12.10.1117/1.3475955

KEYWORDS: Imaging spectroscopy, Atrial fibrillation, Tissue optics, Endoscopy, In vivo imaging, Spectroscopy, Tissues, Diffuse reflectance spectroscopy, Reflectance spectroscopy, Head

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SPIE Journal Paper | 1 May 2010 Open Access

In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy

Zhiwei Huang, Mads Sylvest Bergholt, Wei Zheng, Kan Lin, Khek-Yu Ho, Ming The, Khay-Guan Yeoh

JBO, Vol. 15, Issue 03, 037017, (May 2010) https://doi.org/10.1117/12.10.1117/1.3420115

KEYWORDS: Raman spectroscopy, Tissues, In vivo imaging, Endoscopy, Diagnostics, Laser tissue interaction, Proteins, Cancer, Signal detection, Imaging systems

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SPIE Journal Paper | 1 March 2010 Open Access

Rapid near-infrared fluorescence excitation-emission matrix spectroscopy for multifluorophore characterization using an acousto-optic tunable filter technique

Hao Li, Wei Zheng, Zhiwei Huang

JBO, Vol. 15, Issue 02, 027010, (March 2010) https://doi.org/10.1117/12.10.1117/1.3374051

KEYWORDS: Luminescence, Optical filters, Near infrared, Fluorescence spectroscopy, Near infrared spectroscopy, Spectroscopy, Polarizers, Tunable filters, Polarization, Acousto-optics

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Proceedings Article | 26 February 2010 Paper

Annular aperture detection scheme in radially polarized coherent anti-Stokes Raman scattering (RP-CARS) microscopy for contrast improvement

Jian Lin, Fake Lu, Haifeng Wang, Wei Zheng, C. J. Sheppard, Zhiwei Huang

Proceedings Volume 7569, 756939 (2010) https://doi.org/10.1117/12.842942

KEYWORDS: Microscopy, CARS tomography, Finite-difference time-domain method, Objectives, Signal detection, Medical research, Polarized microscopy, 3D image processing, Confocal microscopy, Multiphoton microscopy

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Proceedings Article | 26 February 2010 Paper

Assessment of fibrotic liver disease with multimodal nonlinear optical microscopy

Fake Lu, Wei Zheng, Dean C. S. Tai, Jian Lin, Hanry Yu, Zhiwei Huang

Proceedings Volume 7569, 75691W (2010) https://doi.org/10.1117/12.843127

KEYWORDS: Liver, Collagen, Microscopy, Tissues, Optical microscopy, Second-harmonic generation, CARS tomography, Optical fibers, Medical research, Multiphoton microscopy

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Proceedings Article | 23 February 2010 Paper

In vivo Raman spectroscopy integrated with multimodal endoscopic imaging for early diagnosis of gastric dysplasia

Mads Sylvest Bergholt, Wei Zheng, Kan Lin, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Proceedings Volume 7560, 756003 (2010) https://doi.org/10.1117/12.841822

KEYWORDS: Raman spectroscopy, In vivo imaging, Tissues, Endoscopy, Near infrared, Multimodal imaging, Imaging systems, Proteins, Tissue optics, Medical research

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Proceedings Article | 25 November 2009 Paper

Coherent anti-stokes Raman scattering (RP-CARS) microscopy for sensing molecular orientations

Wei Zheng, Zhiwei Huang

Proceedings Volume 7634, 76340V (2009) https://doi.org/10.1117/12.854965

KEYWORDS: CARS tomography, Microscopy, Molecules, Nanoparticles, Polarization, Finite-difference time-domain method, Near field, Microscopes, Polarized microscopy, Confocal microscopy

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Proceedings Article | 23 February 2009 Paper

Image-guided near-infrared Raman spectroscopy for in vivo detection of gastric dysplasia

Zhiwei Huang, Seng Khoon Teh, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh

Proceedings Volume 7169, 71690E (2009) https://doi.org/10.1117/12.807821

KEYWORDS: Raman spectroscopy, In vivo imaging, Tissues, Near infrared, Diagnostics, Endoscopy, Imaging systems, Medical research, Tissue optics, Medicine

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SPIE Journal Paper | 1 November 2008 Open Access

Improving surface-enhanced Raman scattering effect using gold-coated hierarchical polystyrene bead substrates modified with postgrowth microwave treatment

Clement Yuen, Wei Zheng, Zhiwei Huang

JBO, Vol. 13, Issue 06, 064040, (November 2008) https://doi.org/10.1117/12.10.1117/1.3050447

KEYWORDS: Gold, Picosecond phenomena, Surface enhanced Raman spectroscopy, Microwave radiation, Medium wave, Raman scattering, Rhodium, Nanostructures, Raman spectroscopy, Surface roughness

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SPIE Journal Paper | 1 May 2008 Open Access

Diagnosis of gastric cancer using near-infrared Raman spectroscopy and classification and regression tree techniques

Seng Teh, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

JBO, Vol. 13, Issue 03, 034013, (May 2008) https://doi.org/10.1117/12.10.1117/1.2939406

KEYWORDS: Raman spectroscopy, Tissues, Cancer, Diagnostics, Data modeling, Tissue optics, Algorithm development, Tumor growth modeling, Near infrared, Pathology

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Proceedings Article | 21 February 2008 Paper

A specially modified surface-enhanced Raman spectroscopy (SERS) substrate for biomedical applications

Clement Yuen, Wei Zheng, Zhiwei Huang

Proceedings Volume 6869, 686905 (2008) https://doi.org/10.1117/12.762434

KEYWORDS: Surface enhanced Raman spectroscopy, Microwave radiation, Gold, Biomedical optics, Scanning electron microscopy, Medical research, Biological research, Raman spectroscopy, Nanostructures, Raman scattering

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Proceedings Article | 15 February 2008 Paper

High contrast bioimaging using interferometric polarization coherent anti-Stokes Raman scattering microscopy

Fake Lu, Wei Zheng, Zhiwei Huang

Proceedings Volume 6860, 68600Z (2008) https://doi.org/10.1117/12.761547

KEYWORDS: Polarization, Interferometry, CARS tomography, Microscopy, Signal detection, Medical research, Molecules, Signal generators, Multiphoton microscopy, Raman scattering

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Proceedings Article | 12 February 2008 Paper

Autofluorescence spectroscopic imaging for laryngeal cancer detection

Lin Kan, Wei Zheng, Zhiwei Huang

Proceedings Volume 6848, 68480G (2008) https://doi.org/10.1117/12.762249

KEYWORDS: Imaging spectroscopy, Cancer, Spectroscopy, Imaging systems, Tissue optics, Head, Neck, Diagnostics, Tissues, Auto-fluorescence imaging

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Proceedings Article | 12 February 2008 Paper

Near-infrared fluorescence imaging for colonic cancer detection

Xiaozhuo Shao, Jianhua Mo, Wei Zheng, Zhiwei Huang

Proceedings Volume 6848, 68480F (2008) https://doi.org/10.1117/12.761463

KEYWORDS: Cancer, Near infrared, Tissues, Luminescence, Colorectal cancer, Reflectivity, Imaging systems, Medical research, Colon, Diagnostics

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Proceedings Article | 12 February 2008 Paper

Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements

Franck Jaillon, Wei Zheng, Zhiwei Huang

Proceedings Volume 6849, 68490E (2008) https://doi.org/10.1117/12.762177

KEYWORDS: Luminescence, Tissues, Photons, Signal detection, Scattering, Monte Carlo methods, Fluorescence spectroscopy, Fiber couplers, Refractive index, Linear filtering

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Proceedings Article | 8 February 2008 Paper

Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy

Jianhua Zhao, Zhiwei Huang, Haishan Zeng, David McLean, Harvey Lui

Proceedings Volume 6842, 684209 (2008) https://doi.org/10.1117/12.769373

KEYWORDS: Raman spectroscopy, Skin, Quantitative analysis, Molecules, Luminescence, Chemical analysis, Cancer, Spectrographs, Skin cancer, Tissues

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Proceedings Article | 8 February 2008 Paper

Raman spectroscopy for optical diagnosis of laryngeal cancer

Seng Khoon Teh, Wei Zheng, David Lau, Zhiwei Huang

Proceedings Volume 6842, 68421S (2008) https://doi.org/10.1117/12.761432

KEYWORDS: Raman spectroscopy, Tissues, Cancer, Diagnostics, Near infrared, Tumors, Algorithm development, Proteins, Tissue optics, Medical research

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Proceedings Article | 8 February 2008 Paper

Near-infrared autofluorescence spectroscopy for in vivo diagnosis of cervical precancer

Jianhua Mo, Wei Zheng, Jeffrey Low, Joseph Ng, A. Ilancheran, Zhiwei Huang

Proceedings Volume 6853, 685317 (2008) https://doi.org/10.1117/12.762181

KEYWORDS: Near infrared, Spectroscopy, Cervix, In vivo imaging, Near infrared spectroscopy, Diagnostics, Principal component analysis, Tissues, Algorithm development, Cancer

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Proceedings Article | 18 January 2008 Paper

Saliva analysis using surface-enhanced Raman spectroscopy technique

Clement Yuen, Wei Zheng, Zhiwei Huang

Proceedings Volume 6826, 682610 (2008) https://doi.org/10.1117/12.755250

KEYWORDS: Surface enhanced Raman spectroscopy, Gold, Microwave radiation, Raman scattering, Nanostructures, Raman spectroscopy, Picosecond phenomena, Biomedical optics, Scanning electron microscopy, Medical research

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Proceedings Article | 8 January 2008 Paper

Novel coherent anti-stokes Raman scattering microscopy for high contrast bioimaging

Fake Lu, Wei Zheng, Zhiwei Huang

Proceedings Volume 6826, 68260Y (2008) https://doi.org/10.1117/12.755556

KEYWORDS: Polarization, Microscopy, CARS tomography, Signal detection, Medical research, Tissues, Signal attenuation, Luminescence, Biomedical optics, Beam splitters

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Proceedings Article | 19 November 2007 Paper

Near-infrared Raman spectroscopy for optical diagnosis of gastric precancer

Seng Khoon Teh, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Proceedings Volume 6826, 682625 (2007) https://doi.org/10.1117/12.755370

KEYWORDS: Raman spectroscopy, Tissues, Near infrared, Proteins, Tissue optics, Molecular spectroscopy, Cancer, Medicine, Spectroscopy, Diagnostics

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Proceedings Article | 19 November 2007 Paper

Novel fiber-optic probe design for depth-resolved fluorescence measurements: Monte Carlo simulations

Franck Jaillon, Wei Zheng, Zhiwei Huang

Proceedings Volume 6826, 68261D (2007) https://doi.org/10.1117/12.755262

KEYWORDS: Luminescence, Tissues, Monte Carlo methods, Scattering, Fiber optics tests, Fiber optics, Fluorescence spectroscopy, Diagnostics, Refractive index, Medical research

Read Abstract +

SPIE Journal Paper | 1 May 2006 Open Access

Cutaneous melanin exhibiting fluorescence emission under near-infrared light excitation

Zhiwei Huang, Haishan Zeng, Iltefat Hamzavi, Abdulmajeed Alajlan, Eileen Tan, David McLean, Harvey Lui

JBO, Vol. 11, Issue 03, 034010, (May 2006) https://doi.org/10.1117/12.10.1117/1.2204007

KEYWORDS: Skin, Near infrared, Luminescence, Visible radiation, In vivo imaging, Tissue optics, Spectroscopy, In vitro testing, Raman spectroscopy, Ultraviolet radiation

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Proceedings Article | 27 February 2006 Paper

Classification of colonic tissues using Raman spectroscopy and multivariate techniques

Zhiwei Huang, Wei Zheng, Effendi Widjaja, Jianhua Mo, Colin Sheppard

Proceedings Volume 6093, 60930Q (2006) https://doi.org/10.1117/12.647384

KEYWORDS: Tissues, Raman spectroscopy, Cancer, Diagnostics, Near infrared, Tumors, Colorectal cancer, Colon, Algorithm development, Medical research

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Proceedings Article | 8 October 2005 Paper

Classification of ENT tissue using near-infrared Raman spectroscopy and support vector machines

Effendi Widjaja, Wei Zheng, Huang Zhiwei

Proceedings Volume 5862, 586205 (2005) https://doi.org/10.1117/12.633007

KEYWORDS: Raman spectroscopy, Principal component analysis, Tissues, Diagnostics, Tissue optics, Spectroscopy, Algorithm development, Pattern recognition, Detection and tracking algorithms, Biomedical optics

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Proceedings Article | 8 October 2005 Paper

Near-infrared Raman spectroscopy for colonic cancer diagnosis

Zhiwei Huang, Wei Zheng, Sheppard Colin

Proceedings Volume 5862, 586204 (2005) https://doi.org/10.1117/12.633006

KEYWORDS: Tissues, Raman spectroscopy, Cancer, Diagnostics, Near infrared, Tumors, Collagen, Colorectal cancer, Colon, In vivo imaging

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Proceedings Article | 18 January 2005 Paper

Near-infrared Raman spectroscopy detects lung cancer

Zhiwei Huang, Harvey Lui, Annette McWilliams, Stephen Lam, David McLean, Haishan Zeng

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.577419

KEYWORDS: Tissues, Raman spectroscopy, Tumors, Lung cancer, Tissue optics, Near infrared, Proteins, Cancer, Diagnostics, Luminescence

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SPIE Journal Paper | 1 November 2004 Open Access

Raman spectroscopy of in vivo cutaneous melanin

Zhiwei Huang, Harvey Lui, Michael Chen, Abdulmajeed Alajlan, David McLean, Haishan Zeng

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1805553

KEYWORDS: Raman spectroscopy, Skin, In vivo imaging, Melanoma, Spectroscopy, Cancer, Raman scattering, Near infrared, Absorption, Laser scattering

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Proceedings Article | 30 April 2002 Paper

Determination of optical properties of normal and carcinomatous lung tissues at violet and red wavelengths

Shusen Xie, Hui Li, Buhong Li, Wei Zheng, Zhiwei Huang

Proceedings Volume 4644, (2002) https://doi.org/10.1117/12.464131

KEYWORDS: Tissues, Lung, Tissue optics, Scattering, Optical properties, Signal attenuation, Light scattering, In vitro testing, Natural surfaces, Geometrical optics

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Proceedings Article | 25 October 2001 Paper

Evaluation of variations of biomolecular constituents in human skin in vivo by near-infrared Raman spectroscopy

Zhiwei Huang, Haishan Zeng, Calum MacAulay, Iltefat Hamzavi, David McLean, Harvey Lui

Proceedings Volume 4597, (2001) https://doi.org/10.1117/12.446645

KEYWORDS: Raman spectroscopy, Skin, In vivo imaging, Near infrared, Proteins, Spectrographs, Imaging systems, Molecular spectroscopy, Tissue optics, Tissues

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Proceedings Article | 25 October 2001 Paper

Autofluorescence diagnostic algorithm for detecting malignant colonic tissues

Zhiwei Huang, Wei Zheng, Teck-Chee Chia, Cheong Hoong Diong, Tuan-Kay Lim, Francis Seow, Haishan Zeng, Calum MacAulay, D. Maclean, Harvey Lui

Proceedings Volume 4597, (2001) https://doi.org/10.1117/12.446650

KEYWORDS: Tissues, Diagnostics, Luminescence, Cancer, Colon, Visible radiation, Diagnostic tests, Signal detection, Endoscopy, In vitro testing

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Proceedings Article | 18 December 2000 Paper

Laser-induced microscopic fluorescence and images of skin tissues

Zhiwei Huang, Horn Cheah, Teck-Chee Chia, Tan Ching

Proceedings Volume 4164, (2000) https://doi.org/10.1117/12.410627

KEYWORDS: Tissues, Skin, Luminescence, Skin cancer, Microscopes, Statistical analysis, Cancer, Imaging systems, Microscopy, Helium cadmium lasers

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Proceedings Article | 19 April 2000 Paper

Laser-induced fluorescence spectrum of human colonic tissues by Monte Carlo modeling

Zhiwei Huang, Teck-Chee Chia, Sing Lee, Wei Zheng, Sanjay Krishnan, Tuan-Kay Lim, Horn Cheah, Cheong Hoong Diong, Francis Choen

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382726

KEYWORDS: Tissues, Luminescence, Colon, Monte Carlo methods, Tissue optics, Natural surfaces, Absorption, Blood, Laser induced fluorescence, Data modeling

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Proceedings Article | 11 November 1999 Paper

Autofluorescence spectrum of human lung tissue by Monte Carlo modeling

Wei Zheng, Sanjay Krishnan, Zhiwei Huang, Teck-Chee Chia, Gilbert Chiang, Sing Lee

Proceedings Volume 3897, (1999) https://doi.org/10.1117/12.369296

KEYWORDS: Tissue optics, Luminescence, Tissues, Monte Carlo methods, Laser tissue interaction, Natural surfaces, Cartilage, Geometrical optics, Modeling, Tumor growth modeling

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Proceedings Article | 17 September 1999 Paper

Laser-induced microscopic autofluorescence imaging of human colonic tissues

Zhiwei Huang, Teck-Chee Chia, Sing Lee, Wei Zheng, Sanjay Krishnan, Tuan-Kay Lim, Shusen Xie

Proceedings Volume 3863, (1999) https://doi.org/10.1117/12.364405

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Proceedings Article | 17 September 1999 Paper

Laser-induced fluorescence microscopy of human lung tissues

Wei Zheng, Sanjay Krishnan, Zhiwei Huang, Teck-Chee Chia, Shusen Xie, Sing Lee

Proceedings Volume 3863, (1999) https://doi.org/10.1117/12.364404

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Proceedings Article | 19 January 1999 Paper

Changes in autofluorescence emission intensities of human colonic tissues due to photobleaching process

Teck-Chee Chia, Zhiwei Huang, Wei Zheng, Cheong Hoong Diong, Francis Seow

Proceedings Volume 3568, (1999) https://doi.org/10.1117/12.336838

KEYWORDS: Tissues, Luminescence, Molecules, Colon, Natural surfaces, Tissue optics, Monte Carlo methods, In vitro testing, Biopsy, Helium neon lasers

Read Abstract +

Proceedings Article | 2 November 1998 Paper

Optical properties of normal and carcinomatous human lung tissues at 406.7 ~ 415.4 nm of a violet Kr+ laser

Shusen Xie, Wei Zheng, Qirong Lin, Buhong Li, Zhiwei Huang, Teck-Chee Chia

Proceedings Volume 3344, (1998) https://doi.org/10.1117/12.330161

KEYWORDS: Tissues, Lung, Optical properties, Tissue optics, Diffuse reflectance spectroscopy, Scattering, Natural surfaces, Absorption, Laser scattering, Signal attenuation

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Proceedings Article | 7 August 1998 Paper

Fluence rate distributions in human lung tissues at 676.4 nm in vitro

Wei Zheng, Zhiwei Huang, Shusen Xie, Teck-Chee Chia

Proceedings Volume 3548, (1998) https://doi.org/10.1117/12.317878

KEYWORDS: Tissues, Lung, Monte Carlo methods, Lung cancer, Krypton, Optical properties, Natural surfaces, In vitro testing, Photodynamic therapy, Light scattering

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Proceedings Article | 7 August 1998 Paper

Fluorescence spectroscopy of human colon tissues

Zhiwei Huang, Teck-Chee Chia, Wei Zheng, Shusen Xie, Cheong Hoong Diong, Seow Francis

Proceedings Volume 3548, (1998) https://doi.org/10.1117/12.317881

KEYWORDS: Tissues, Luminescence, Colon, Tumors, Fluorescence spectroscopy, Signal attenuation, Visible radiation, In vitro testing, Laser induced fluorescence, Laser irradiation

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Proceedings Article | 16 April 1998 Paper

Laser-induced autofluorescence of human colonic tissues

Zhiwei Huang, Teck-Chee Chia, Cheong Hoong Diong, Sing Lee, Seow Francis

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305382

KEYWORDS: Tissues, Tumors, Luminescence, Colon, Laser spectroscopy, Fluorescence spectroscopy, Spectroscopy, Visible radiation, Diagnostics, Fiber lasers

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Proceedings Article | 14 January 1998 Paper

Light distribution in human lung tissue at 413.1 nm in vitro

Zhiwei Huang, Chee Chia, Cheong Hoong Diong, Sing Lee, Wei-Ming Zheng, Shusen Xie

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297878

KEYWORDS: Tissues, Lung, Monte Carlo methods, Optical properties, In vitro testing, Natural surfaces, Lung cancer, Optical testing, Reflection, Signal attenuation

Read Abstract +

Proceedings Article | 23 September 1996 Paper

Principles and techniques for measuring optical parameters of biotissue

Shusen Xie, Hui Li, Wei Zheng, Teck-Chee Chia, Sing Lee, Zhiwei Huang

Proceedings Volume 2887, (1996) https://doi.org/10.1117/12.251937

KEYWORDS: Tissue optics, Tissues, Scattering, Light scattering, Refractive index, Optical properties, Diffusion, Reflectivity, Absorption, Skin

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Proceedings Article | 23 September 1996 Paper

Lifetimes of normal and tumorous human lung tissues by time-resolved fluorescence spectra

Wei Zheng, Zhiwei Huang, Shusen Xie, Teck-Chee Chia, Zukang Lu, Jin Chen

Proceedings Volume 2887, (1996) https://doi.org/10.1117/12.251945

KEYWORDS: Tissues, Luminescence, Lung, Tumors, Time resolved spectroscopy, Lung cancer, Dye lasers, In vitro testing, Natural surfaces, Q switched lasers

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Showing 5 of 95 publications

Proceedings Volume Editor (5)

SPIE Conference Volume | 26 March 2024

Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry

SPIE Conference Volume | 31 August 2023

Translational Biophotonics: Diagnostics and Therapeutics III

SPIE Conference Volume | 29 March 2022

Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry

SPIE Conference Volume | 7 December 2021

Translational Biophotonics: Diagnostics and Therapeutics

SPIE Conference Volume | 5 March 2020

Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry

Conference Committee Involvement (31)

Advanced Chemical Microscopy for Life Science and Translational Medicine 2025

25 January 2025 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXIII

25 January 2025 | San Francisco, California, United States

Optical Biopsy XXIII: Toward Real-Time Spectroscopic Imaging and Diagnosis

25 January 2025 | San Francisco, California, United States

Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis

30 January 2024 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII

27 January 2024 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry

27 January 2024 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2024

27 January 2024 | San Francisco, California, United States

Translational Biophotonics: Diagnostics and Therapeutics

25 June 2023 | Munich, Germany

Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis

31 January 2023 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2023

28 January 2023 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI

28 January 2023 | San Francisco, California, United States

Optical Biopsy XX: Toward Real-Time Spectroscopic Imaging and Diagnosis

25 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2022

23 January 2022 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX

23 January 2022 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry

22 January 2022 | San Francisco, California, United States

Translational Biophotonics: Diagnostics and Therapeutics

20 June 2021 | Online Only, Germany

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

6 March 2021 | Online Only, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX

6 March 2021 | Online Only, California, United States

Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis

6 March 2021 | Online Only, California, United States

Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis

2 February 2020 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVIII

2 February 2020 | San Francisco, California, United States

Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry

1 February 2020 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine

1 February 2020 | San Francisco, California, United States

Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis

5 February 2019 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII

3 February 2019 | San Francisco, California, United States

Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis

30 January 2018 | San Francisco, California, United States

Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis

31 January 2017 | San Francisco, California, United States

Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis

15 February 2016 | San Francisco, California, United States

Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis

10 February 2015 | San Francisco, California, United States

Optical Biopsy XII

4 February 2014 | San Francisco, California, United States

Optical Biopsy XI

5 February 2013 | San Francisco, California, United States

Showing 5 of 31 Conference Committees

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