Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study

Jianfeng Wang; Kan Lin; Wei Zheng; Khek Yu Ho; Ming Teh; Khay Guan Yeoh; Zhiwei Huang

doi:10.1117/12.2212067

7 March 2016 Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study

Jianfeng Wang, Kan Lin, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang

Author Affiliations +

Proceedings Volume 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry; 97040D (2016) https://doi.org/10.1117/12.2212067
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Raman spectroscopy is a unique optical vibrational spectroscopic technique which is capable of probing biochemical and biomolecular structures and conformations associated with disease transformation. Raman probe is a key component to facilitate the in vivo tissue diagnosis by using Raman spectroscopy. The diagnostic performance of the two different endoscope-based fiber-optic Raman probe designs (i.e., beveled and volume Raman probes) were evaluated for real-time, in vivo diagnosis of gastric dysplasia at endoscopy. The beveled Raman probe provides approximately 2-fold improvements in tissue Raman to autofluorescence intensity ratios as compared to the use of volume Raman probe. The diagnostic accuracy of gastric dysplasia using beveled Raman probe is 93.0% (sensitivity of 92.5%; specificity of 93.1%), which is superior to the diagnostic performance (accuracy of 88.4%; sensitivity of 85.8%; specificity of 88.6%) using the volume Raman probe. Biomolecular modeling is finally employed to extract the different Raman active components interrogated by the two types of endoscope-based Raman probes.

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Jianfeng Wang, Kan Lin, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, and Zhiwei Huang "Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study", Proc. SPIE 9704, Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 97040D (7 March 2016); https://doi.org/10.1117/12.2212067

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KEYWORDS

Raman spectroscopy

Fiber optics

Tissues

In vivo imaging

Endoscopy

Diagnostics

Cancer

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