Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin; Wei Zheng; Jianfeng Wang; Chwee Ming Lim; Zhiwei Huang

doi:10.1117/12.2213964

29 February 2016 Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, Zhiwei Huang

Author Affiliations +

Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96892B (2016) https://doi.org/10.1117/12.2213964
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ~85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.

Citation Download Citation

Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, and Zhiwei Huang "Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96892B (29 February 2016); https://doi.org/10.1117/12.2213964

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