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13 March 2024 Label-free monitoring of microplastics and lipid metabolism in live zebrafish with hyperspectral stimulated Raman scattering microscopy
Le Xin, Zhiwei Huang
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Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC128390L (2024) https://doi.org/10.1117/12.3008490
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We employ spectral focusing hyperspectral stimulated Raman scattering (SRS) imaging for longitudinal 3D label-free visualization of microplastics (MP) and biomolecules within live zebrafish throughout the development process. We investigated the uptake routes and size-dependent bioaccumulation of MP in various zebrafish organs across different developmental stages. The altered lipid metabolic dynamics identified by biorthogonal hyperspectral SRS imaging further reveal the hepatic inflammation and energy metabolism disruptions in MP-exposed zebrafish, thus shedding new light on the fate and potential impacts of MP on diverse living organisms.
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Le Xin and Zhiwei Huang "Label-free monitoring of microplastics and lipid metabolism in live zebrafish with hyperspectral stimulated Raman scattering microscopy", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC128390L (13 March 2024); https://doi.org/10.1117/12.3008490
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KEYWORDS
Microscopy
Mode conditioning cables
Raman scattering
Biological imaging
Liver
Picosecond phenomena
Brain
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