Autofluorescence spectrum of human lung tissue by Monte Carlo modeling

Wei Zheng; Sanjay M. Krishnan; Zhiwei Huang; Teck-Chee Chia; Gilbert Chiang; Sing Lee

doi:10.1117/12.369296

11 November 1999 Autofluorescence spectrum of human lung tissue by Monte Carlo modeling

Wei Zheng, Sanjay M. Krishnan, Zhiwei Huang, Teck-Chee Chia, Gilbert Chiang, Sing Lee

Proceedings Volume 3897, Advanced Photonic Sensors and Applications; (1999) https://doi.org/10.1117/12.369296
Event: International Symposium on Photonics and Applications, 1999, Singapore, Singapore

Abstract

Based on tissue microscopic fluorescence properties and optical parameters, a three-layer bronchus optical mode was developed to calculate the excitation light distribution in the tissue and the fluorescence escape function from the tissue by Monte Carlo simulations. The contributions of each layer in the tissue to total autofluorescence signal observed at the tissue surface were also estimated. In addition, the fluorescence spectrum of the bronchial tissue was also modeled using the obtained tissue micro- spectroscopic properties. It is found that the theoretically modeled spectrum agrees well with the in vitro tissue fluorescence in the spectral range below 520 nm or above 600 nm.

Citation Download Citation

Wei Zheng, Sanjay M. Krishnan, Zhiwei Huang, Teck-Chee Chia, Gilbert Chiang, and Sing Lee "Autofluorescence spectrum of human lung tissue by Monte Carlo modeling", Proc. SPIE 3897, Advanced Photonic Sensors and Applications, (11 November 1999); https://doi.org/10.1117/12.369296

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