Laser-induced fluorescence spectrum of human colonic tissues by Monte Carlo modeling

Zhiwei Huang; Teck-Chee Chia; Sing Lee; Wei Zheng; Sanjay M. Krishnan; Tuan-Kay Lim; Horn Mun Cheah; Cheong Hoong Diong; Francis Seow Choen

doi:10.1117/12.382726

19 April 2000 Laser-induced fluorescence spectrum of human colonic tissues by Monte Carlo modeling

Zhiwei Huang, Teck-Chee Chia, Sing Lee, Wei Zheng, Sanjay M. Krishnan, Tuan-Kay Lim, Horn Mun Cheah, Cheong Hoong Diong, Francis Seow Choen

Author Affiliations +

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382726
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Based on the microscopic properties of colonic tissues, a five-layer colon optical model was developed to calculate the excitation light distribution in the tissue and the fluorescence escape function from the tissue by Monte Carlo simulations. The theoretically modeled fluorescence spectrum fits well to the experimental results, demonstrating that the microscopic properties of tissue applied in the colon optical model can be quantitatively correlated with the macroscopic autofluorescence measurements.

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Zhiwei Huang, Teck-Chee Chia, Sing Lee, Wei Zheng, Sanjay M. Krishnan, Tuan-Kay Lim, Horn Mun Cheah, Cheong Hoong Diong, and Francis Seow Choen "Laser-induced fluorescence spectrum of human colonic tissues by Monte Carlo modeling", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382726

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