Fiberoptic Raman endoscopy enables intraoperative, real-time, in vivo bladder cancer diagnosis

Chi Shu; Carmen Ka Man Yu; Chang Liu; Bocheng Qiu; Zhiwei Huang; Arshvin Kesavan; Edmund Chiong

doi:10.1117/12.3008510

13 March 2024 Fiberoptic Raman endoscopy enables intraoperative, real-time, in vivo bladder cancer diagnosis

Chi Shu, Carmen Ka Man Yu, Chang Liu, Bocheng Qiu, Zhiwei Huang, Arshvin Kesavan, Edmund Chiong

Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC128390A (2024) https://doi.org/10.1117/12.3008510
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We report on the development of a simultaneous fingerprint and high-wavenumber (FP/HW) Raman endoscopy platform for real-time, in vivo diagnosis of bladder cancer during transurethral resection of bladder tumor (TURBT). Significant tissue Raman spectral differences are observed in both FP (i.e., 800 – 1800 cm^-1) and HW (i.e., 2800 – 3600 cm^-1) regions between normal and cancer as well as between normal and carcinoma in situ (CIS) tissue sites, indicating the biomolecular differences among cancer, CIS and normal tissue sites. A cancer diagnosis model has been developed based on partial-least-squares linear-discriminant-analysis (PLS-LDA) with leave-one-tissue site-out cross-validation (LOOCV). The diagnosis model yields the diagnostic accuracy of > 90 % for identifying both cancer and CIS sites from normal bladder tissue. Through this work, we demonstrate that in vivo FP/HW fiberoptic Raman endoscopy is a promising and effective clinical tool for rapid diagnosis of cancer and pre-cancer tissue sites during TURBT from biomolecular level.

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Citation Download Citation

Chi Shu, Carmen Ka Man Yu, Chang Liu, Bocheng Qiu, Zhiwei Huang, Arshvin Kesavan, and Edmund Chiong "Fiberoptic Raman endoscopy enables intraoperative, real-time, in vivo bladder cancer diagnosis", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC128390A (13 March 2024); https://doi.org/10.1117/12.3008510

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KEYWORDS

Raman spectroscopy

Bladder cancer

Endoscopy

Cancer

Fiber optics

Tissues

Biomolecules

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