Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy

Jianhua Zhao; Zhiwei Huang; Haishan Zeng; David I. McLean M.D.; Harvey Lui M.D.

doi:10.1117/12.769373

8 February 2008 Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy

Jianhua Zhao, Zhiwei Huang, Haishan Zeng, David I. McLean M.D., Harvey Lui M.D.

Proceedings Volume 6842, Photonic Therapeutics and Diagnostics IV; 684209 (2008) https://doi.org/10.1117/12.769373
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Raman spectroscopy is a non-invasive optical technique that is very sensitive to the structure and conformation of biochemical constitutes. It has been successfully used to study dysplasia and cancer in a variety of human tissues including skin. Researchers have a strong interest in quantitative analysis of the Raman spectra in the hope to find the quantitative molecule changes associated with cancers. Because skin is the largest organ in humans, it is very important to study the variability of Raman spectra for different body sites. In this presentation we report our quantitative analysis of normal skin Raman spectra of twenty-five body sites. Partial least square (PLS) analysis was used to quantify the skin molecules from the in vivo Raman spectra. We find that the absolute Raman intensity differs from person to person and from body site to body site. However the normalized Raman spectra are identical for the same body site. It is particularly interesting to find that the distribution of skin molecules is clustered for the same body regions.

Citation Download Citation

Jianhua Zhao, Zhiwei Huang, Haishan Zeng, David I. McLean M.D., and Harvey Lui M.D. "Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy", Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684209 (8 February 2008); https://doi.org/10.1117/12.769373

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