Real-time recurrent nasopharyngeal carcinoma diagnosis and treatment efficacy follow-up at endoscopy using fiberoptic Raman spectroscopy

Chi Shu; Zhiwei Huang; Wei Zheng; Kan Lin; Chweeming Lim

doi:10.1117/12.2607349

7 March 2022 Real-time recurrent nasopharyngeal carcinoma diagnosis and treatment efficacy follow-up at endoscopy using fiberoptic Raman spectroscopy

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, Chweeming Lim

Author Affiliations +

Proceedings Volume PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; PC119570C (2022) https://doi.org/10.1117/12.2607349
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this study, we applied a unique fiberoptic Raman spectroscopy probe to access the post-treatment NPC treatment efficacy follow-up and accurate recurrent NPC diagnosis. Significant Raman feature differences are discovered among normal, NPC, and non-recurring post-treatment patients. By incorporating with partial-least-squares linear-discriminant-analysis (PLS-LDA), the in vivo fingerprint and high-wavenumber tissue Raman spectra provide high diagnostic accuracy for detecting recurrent NPC from both early post-treatment inflammation and long-term post-treatment fibrosis. We further investigate the major biochemicals associated with NPC tissue compared to normal nasopharyngeal tissue through quantitative modeling. In this work, we demonstrate that fiberoptic Raman spectroscopy is an effective diagnostic modality for real-time, label-free post-treatment surveying and recurrent tumor detection in NPC patients.

Conference Presentation

Citation Download Citation

Chi Shu, Zhiwei Huang, Wei Zheng, Kan Lin, and Chweeming Lim "Real-time recurrent nasopharyngeal carcinoma diagnosis and treatment efficacy follow-up at endoscopy using fiberoptic Raman spectroscopy", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570C (7 March 2022); https://doi.org/10.1117/12.2607349

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KEYWORDS

Raman spectroscopy

Fiber optics

Endoscopy

Diagnostics

Tissues

Collagen

Inflammation

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