Autofluorescence spectroscopic imaging for laryngeal cancer detection

Lin Kan; Wei Zheng; Zhiwei Huang

doi:10.1117/12.762249

12 February 2008 Autofluorescence spectroscopic imaging for laryngeal cancer detection

Lin Kan, Wei Zheng, Zhiwei Huang

Proceedings Volume 6848, Advanced Biomedical and Clinical Diagnostic Systems VI; 68480G (2008) https://doi.org/10.1117/12.762249
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Autofluorescence imaging has shown a high sensitivity for early diagnosis and detection of cancer and precancer in humans, however, this diagnostic technique has a limitation with high false positive rates resulting in a low diagnostic specificity. In this study, we develop an endoscope-based autofluorescence imaging system in combination with spectroscopy measurement system for tissue diagnostics and characterization in the head and neck. The results show that combining the spectroscopy and imaging techniques can improve both the diagnostic sensitivity and specificity for discriminating laryngeal carcinoma from normal tissue.

Citation Download Citation

Lin Kan, Wei Zheng, and Zhiwei Huang "Autofluorescence spectroscopic imaging for laryngeal cancer detection", Proc. SPIE 6848, Advanced Biomedical and Clinical Diagnostic Systems VI, 68480G (12 February 2008); https://doi.org/10.1117/12.762249

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