Configurable cloud based medical laser platform with real-time treatment monitoring

Visa Kaivosoja; Zoe Ylöniemi; Juha Lemmetti; Timo Tanila; Lasse Orsila; Petteri Uusimaa

doi:10.1117/12.2577442

5 March 2021 Configurable cloud based medical laser platform with real-time treatment monitoring

Visa Kaivosoja, Zoe Ylöniemi, Juha Lemmetti, Timo Tanila, Lasse Orsila, Petteri Uusimaa

Proceedings Volume 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation; 116280Q (2021) https://doi.org/10.1117/12.2577442
Event: SPIE BiOS, 2021, Online Only

Abstract

Traditionally one of the biggest challenges with light-based treatment modalities such as photodynamic therapy or different tumor ablation techniques is to determine how much light should be applied to the tissue and how that will be distributed to activate a bio-photonic process or a drug. Different tools have been developed to model light distribution in tissue, but this has not solved the problem of how to know what happens in the tissue during the treatment. Modulight has assessed this problem and developed a state-of-the-art laser platform with real-time treatment monitoring capability. Modulight ML7710i platform enables illumination and detection with up to eight illumination channels on same or different wavelength(s). Spectral measurements can be measured and collected with the same fibers that are used for illumination which is minimally invasive and eliminates the need for complicated measurement set-ups with moving fibers around in the tumor tissue or having separate monitoring probes. The system also is connected to cloud making treatment planning, data collection and analysis easy and reliable enabling machine learning and AI based medicine in the future. ML7710i type of medical device makes it possible not only to measure the light intensity at tumor margins but also monitor the progress of the treatment by measuring photosensitizer photobleaching, drug release or activation of multimodal drugs. Photobleaching monitoring with ML7710i is currently utilized in 5-ALA mediated clinical trials for glioblastoma and the data looks very promising. In addition, also drug release from novel light activated nanoparticles or other drug carriers can be effectively monitored for pharmaceuticals that possess fluorescent potential or carry fluorescence labels.

Conference Presentation

Citation Download Citation

Visa Kaivosoja, Zoe Ylöniemi, Juha Lemmetti, Timo Tanila, Lasse Orsila, and Petteri Uusimaa "Configurable cloud based medical laser platform with real-time treatment monitoring", Proc. SPIE 11628, Mechanisms and Techniques in Photodynamic Therapy and Photobiomodulation, 116280Q (5 March 2021); https://doi.org/10.1117/12.2577442

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