Accurate characterization of phantoms for performance assessment and calibration in diffuse optics

Heidrun Wabnitz; Lin Yang; Thomas Gladytz; Lina Hacker; James Joseph; Dirk Grosenick

doi:10.1117/12.2588994

5 March 2021 Accurate characterization of phantoms for performance assessment and calibration in diffuse optics

Heidrun Wabnitz, Lin Yang, Thomas Gladytz, Lina Hacker, James Joseph, Dirk Grosenick

Proceedings Volume 11633, Design and Quality for Biomedical Technologies XIV; 1163306 (2021) https://doi.org/10.1117/12.2588994
Event: SPIE BiOS, 2021, Online Only

Abstract

We developed refined methods for time-domain measurements of the optical properties of solid homogeneous turbid phantoms. Employing a reliable time-domain reference setup with a stable, narrow, and clean instrument response function and GPU-based Monte-Carlo fitting, 1% accuracy for optical properties seems realistic. An alternative space-enhanced time-domain method that combines spatially resolved amplitude with a time-domain measurement effectively reduced the crosstalk between absorption and scattering. Besides physical phantoms, we explored and characterized a digital phantom that mimics arbitrary time-of-flight distributions via time-dependent attenuation employing a spatial light modulator and a dedicated multi-fiber delay unit. We discuss potential applications in performance tests.

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Heidrun Wabnitz, Lin Yang, Thomas Gladytz, Lina Hacker, James Joseph, and Dirk Grosenick "Accurate characterization of phantoms for performance assessment and calibration in diffuse optics", Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 1163306 (5 March 2021); https://doi.org/10.1117/12.2588994

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KEYWORDS

Diffuse optical imaging

Calibration

Optical calibration

Spatial light modulators

Monte Carlo methods

Optical properties

Reflectivity

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