Oscillation processes in synuclein-KO mouse skin microcirculation: a pilot study

Igor Kozlov; Dmitriy Serov; Evgeniya Seryogina; Maxim Astashev; Arina Tankanag; Kirill Chaprov; Ekaterina Lysikova; Natalia Ninkina; Evgeniy Zherebtsov; Andrey Dunaev

doi:10.1117/12.2626412

29 April 2022 Oscillation processes in synuclein-KO mouse skin microcirculation: a pilot study

Igor Kozlov, Dmitriy Serov, Evgeniya Seryogina, Maxim Astashev, Arina Tankanag, Kirill Chaprov, Ekaterina Lysikova, Natalia Ninkina, Evgeniy Zherebtsov, Andrey Dunaev

Author Affiliations +

Proceedings Volume 12192, Optical Technologies for Biology and Medicine; 121920W (2022) https://doi.org/10.1117/12.2626412
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

The article is devoted to the analysis of skin perfusion oscillation processes with wild-type and synuclein-deficient mice with three knockout (KO) types: αγ-KO, β-KO, and αβγ-KO. The role of synucleins in tissues that exclude the central nervous system remains sparsely studied. Laser Doppler flowmetry was used to investigate the potential involvement of synucleins in murine microcirculation functioning This method is widely used to analyze microcirculatory disturbances in a variety of pathologies and has proven to be sensitive to the manifestation of abnormalities of normal function. The study revealed that deficiency of β-synuclein affects oscillation processes more than αγ-synuclein deficiency.

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Igor Kozlov, Dmitriy Serov, Evgeniya Seryogina, Maxim Astashev, Arina Tankanag, Kirill Chaprov, Ekaterina Lysikova, Natalia Ninkina, Evgeniy Zherebtsov, and Andrey Dunaev "Oscillation processes in synuclein-KO mouse skin microcirculation: a pilot study", Proc. SPIE 12192, Optical Technologies for Biology and Medicine, 121920W (29 April 2022); https://doi.org/10.1117/12.2626412

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