Monitoring the microenvironment and microvasculature of primary pancreatic tumor under photothermal-induced immunotherapy by optical coherence tomography (Conference Presentation)

Feng Yan; Trisha I. Valerio; Chen Wang; Wei R. Chen; Qinggong Tang

doi:10.1117/12.2651195

14 March 2023 Monitoring the microenvironment and microvasculature of primary pancreatic tumor under photothermal-induced immunotherapy by optical coherence tomography (Conference Presentation)

Feng Yan, Trisha I. Valerio, Chen Wang, Wei R. Chen, Qinggong Tang

Author Affiliations +

Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 123800A (2023) https://doi.org/10.1117/12.2651195
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We utilized optical coherence tomography (OCT) to monitor the longitudinal progression of the microenvironment and microvasculature of pancreatic tumors before and after the photothermal therapy-induced immunotherapy in vivo. The primary pancreatic tumors implanted on mouse legs and treated via the photothermal therapy-induced immunotherapy were observed every three days for 36 days. The intensity-based OCT structure, uniformity, texture, intrinsic optical attenuation contrast, and vascular structures were detected and analyzed. Our result demonstrated that the photothermal-induced immunotherapy could cause significant changes in the distribution of the tissue structure and vasculature within the microenvironment and microvasculature of the primary pancreatic tumors.

Conference Presentation

Citation Download Citation

Feng Yan, Trisha I. Valerio, Chen Wang, Wei R. Chen, and Qinggong Tang "Monitoring the microenvironment and microvasculature of primary pancreatic tumor under photothermal-induced immunotherapy by optical coherence tomography (Conference Presentation)", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 123800A (14 March 2023); https://doi.org/10.1117/12.2651195

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