Research progress on prion protein structure and molecular mechanism of pathogenicity

Yiran Zhao; Xiaoxiang Gong; Songying Jin; Lifan Luo

doi:10.1117/12.2669372

24 March 2023 Research progress on prion protein structure and molecular mechanism of pathogenicity

Yiran Zhao, Xiaoxiang Gong, Songying Jin, Lifan Luo

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261122 (2023) https://doi.org/10.1117/12.2669372
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Transmissible spongiform encephalopathy (TSE), often known as a prion disease, is a lethal condition that affects both humans and animals' central nervous systems. It has a protracted incubation time, a swift course, and a 100 percent fatality rate. Such diseases are one of the serious threats to human health. The spread of the disease among animals (such as bovine spongiform encephalopathy) can also have negative economic, agricultural and medical impacts on societies. Prion diseases are caused by infectious protein particles containing pathogenic isomers of prion proteins. Prion disease is believed to be caused solely by a single protein known as PrP^Sc, which is a diseased form of the prion protein. PrP^Sc occurs when the normal prion protein PrP^C in cells misfolds. However, the underlying pathological mechanism of prion infection in the nervous system is still unknown. There is no cure for prion diseases, and existing drugs are not effective enough to prolong survival. This review will introduce prion structure, susceptibility, pathogenic molecular mechanism and so on.

Citation Download Citation

Yiran Zhao, Xiaoxiang Gong, Songying Jin, and Lifan Luo "Research progress on prion protein structure and molecular mechanism of pathogenicity", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261122 (24 March 2023); https://doi.org/10.1117/12.2669372

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