Evaluation of prostatic optical properties and tissue response to photodynamic therapy in a canine model

Sugandh D. Shetty M.D.; Qun Chen; Daniel Schultz; Brian C. Wilson; Michael S. Patterson; Fred W. Hetzel; Joseph C. Cerny M.D.

doi:10.1117/12.168682

1 March 1994 Evaluation of prostatic optical properties and tissue response to photodynamic therapy in a canine model

Sugandh D. Shetty M.D., Qun Chen, Daniel Schultz, Brian C. Wilson, Michael S. Patterson, Fred W. Hetzel, Joseph C. Cerny M.D.

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168682
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A new modality of interstitial therapy to treat prostate cancer using photodynamic principles has been studied in a canine model. The effect of interstitial application of monochromatic light from an argon pumped dye laser at 630 nm was studied in a canine model. No significant hyperthermia was seen during the treatment. A concentric zone around the treatment fiber was seen during the treatment. A concentric zone around the treatment fiber was seen in PDT treated dogs and the maximum size was 18 mm. The data suggests that PDT may be clinically applicable in achieving tissue necrosis using interstitial light application in a solid organ like prostate.

Citation Download Citation

Sugandh D. Shetty M.D., Qun Chen, Daniel Schultz, Brian C. Wilson, Michael S. Patterson, Fred W. Hetzel, and Joseph C. Cerny M.D. "Evaluation of prostatic optical properties and tissue response to photodynamic therapy in a canine model", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168682

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