Investigation of local heterogeneity of hbO2 and hb in working dog heart in situ under isovolemic hemodilution and critical coronary stenosis

Alfons Krug; Manfred D. Kessler; Raja Khuri; Robert Lust; Randolph Chitwood

doi:10.1117/12.260636

11 December 1996 Investigation of local heterogeneity of hbO₂ and hb in working dog heart in situ under isovolemic hemodilution and critical coronary stenosis

Alfons Krug, Manfred D. Kessler, Raja Khuri, Robert Lust, Randolph Chitwood

Author Affiliations +

Proceedings Volume 2927, Optical and Imaging Techniques for Biomonitoring II; (1996) https://doi.org/10.1117/12.260636
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

A tissue spectrophotometer (EMPHO II) working with 70 micrometer micro lightguide sensors enables recording of spectra in the visible wavelength range (500 - 630 nm). During an initial period arterial hypoxia and hyperoxia were induced on working dog heart by mechanical ventilation with oxygen fractions (fi_O2) of 0.1 and 0.5. Under these conditions the effects of low and high fi_O2 on oxygenation distribution of intracapillary hemoglobin were investigated. In the second part of the experiment the relation between systemic hematocrit, local hemoglobin concentration, local hemoglobin oxygenation and the oxygen regulation mechanism were studied in detail. In the final part of the experiment the effect of critical coronary stenosis on hb and hbO₂ was measured. Critical stenosis was achieved by partial clamping of the left anterior coronary artery (LAD).

Citation Download Citation

Alfons Krug, Manfred D. Kessler, Raja Khuri, Robert Lust, and Randolph Chitwood "Investigation of local heterogeneity of hbO₂ and hb in working dog heart in situ under isovolemic hemodilution and critical coronary stenosis", Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); https://doi.org/10.1117/12.260636

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available