Oxygen effect of photodynamic therapy

Qun Chen; Hua Chen; Juli B. Murphy; Howard Shapiro; Fred W. Hetzel

doi:10.1117/12.273490

8 May 1997 Oxygen effect of photodynamic therapy

Qun Chen, Hua Chen, Juli B. Murphy, Howard Shapiro, Fred W. Hetzel

Proceedings Volume 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI; (1997) https://doi.org/10.1117/12.273490
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) is rapidly becoming an accepted therapeutic modality for the treatment of some types of malignant tumors. An important feature of PDT is its absolute dependence on molecular oxygen during light irradiation.Hypoxic tumor cells, either pre-existing or photochemically depleted of their oxygen supply during light irradiation, are resistant to PDT treatment, and contribute to treatment failures. We hypothesize that tumor response to PDT can be improved by combining PDT with Hyper-oxygenation, which may simultaneously compensate for the oxygen depletion by PDT and increase oxygenation of the pre-existing hypoxic cells. The doubling time of mammary carcinoma tumors, implanted in either leg or flank of C3H mice, was evaluated after PDT treatment with/without addition of hyperoxygenation. By adding hyperoxygenation to a non- curative PDT dose, a further delay in the tumor regrowth was observed. For a sub-curative does PDT treatment, the addition of hyperoxygenation resulted in an increase in tumor cure. The results indicate that tumor response can be improved by combining PDT and hyperoxygenation.

Citation Download Citation

Qun Chen, Hua Chen, Juli B. Murphy, Howard Shapiro, and Fred W. Hetzel "Oxygen effect of photodynamic therapy", Proc. SPIE 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI, (8 May 1997); https://doi.org/10.1117/12.273490

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available