Microelastography of tissue with OCT

Joseph M. Schmitt; Xudong Bao; Shaojun Xiao

doi:10.1117/12.347506

30 April 1999 Microelastography of tissue with OCT

Joseph M. Schmitt, Xudong Bao, Shaojun Xiao

Proceedings Volume 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III; (1999) https://doi.org/10.1117/12.347506
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The goal of OCT elastography is to quantify microscope strain induced inside a tissue by stress applied externally. Images of internal strain or displacement may provide valuable information about pathological processes such as edema and fibrosis which are known to alter the mechanical properties of tissue.In this sty we developed experimental methods for measuring internal deformation in highly scattering tissue with OCT and applied them to tissue phantoms and living tissue. Piezoelectric actuators were configured to compress the samples in steps of 5-10 micrometers as images were captured synchronously using either a frame or a line-by-line acquisition mode. The displacements of structures inside the samples were quantified using speckle- tracking algorithms based on cross correlation or optical flow of selected features. Displacements as small as a few micrometers were measurable in heterogeneous gelatin phantoms containing scattering particles and living skin. The rules suggest that the composition of tissue layers whose elasticities differ greatly can be deduced visually from image sequences without the need for complicated image processing. However, better models are needed to transform the displacement images into quantitative maps of subtle regional variations of the elastic modulus.

Citation Download Citation

Joseph M. Schmitt, Xudong Bao, and Shaojun Xiao "Microelastography of tissue with OCT", Proc. SPIE 3598, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III, (30 April 1999); https://doi.org/10.1117/12.347506

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