Motexafin lutetium in graft coronary artery disease

Kathryn W. Woodburn; Shari L. Rodriquez; Atsushi Yamaguchi; Motoya Hayase; Robert C. Robbins; David Kessel

doi:10.1117/12.379878

29 March 2000 Motexafin lutetium in graft coronary artery disease

Kathryn W. Woodburn, Shari L. Rodriquez, Atsushi Yamaguchi, Motoya Hayase, Robert C. Robbins, David Kessel

Proceedings Volume 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX; (2000) https://doi.org/10.1117/12.379878
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Graft coronary artery disease (GCAD) is the chief complication following cardiac transplantation. Presently, there are limited treatment options. Insights into more expedient diagnosis and amelioration, if only partially, of GCAD are fervently sought. The selectivity of Antrin Injection (Lu-Tex) with subsequent photoactivation has been evaluated in several preclinical atherosclerosis models. The inhibitory effect of Lu-Tex induced photosensitization was demonstrated with human bypass coronary smooth muscle cells. The biodistribution of Lu-Tex was evaluated in a rat model of heterotopic cardiac allografts 60 days following transplantation. Lu-Tex was retained in the cardiac allograft, exhibiting a five-fold increase in retention between the allograft and native heart. These findings lead us to suggest that further studies are warranted to ascertain the merits of Lu-Tex for the diagnosis and possible attenuation of chronic graft vascular disease.

Citation Download Citation

Kathryn W. Woodburn, Shari L. Rodriquez, Atsushi Yamaguchi, Motoya Hayase, Robert C. Robbins, and David Kessel "Motexafin lutetium in graft coronary artery disease", Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); https://doi.org/10.1117/12.379878

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