Micro-CT images reconstruction and 3D visualization for small animal studying

Hui Gong; Qian Liu; Aijun Zhong; Shan Ju; Quan Fang; Zheng Fang

doi:10.1117/12.580577

18 January 2005 Micro-CT images reconstruction and 3D visualization for small animal studying

Hui Gong, Qian Liu, Aijun Zhong, Shan Ju, Quan Fang, Zheng Fang

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.580577
Event: Photonics Asia, 2004, Beijing, China

Abstract

A small-animal x-ray micro computed tomography (micro-CT) system has been constructed to screen laboratory small animals and organs. The micro-CT system consists of dual fiber-optic taper-coupled CCD detectors with a field-of-view of 25x50 mm², a microfocus x-ray source, a rotational subject holder. For accurate localization of rotation center, coincidence between the axis of rotation and centre of image was studied by calibration with a polymethylmethacrylate cylinder. Feldkamp’s filtered back-projection cone-beam algorithm is adopted for three-dimensional reconstruction on account of the effective corn-beam angle is 5.67° of the micro-CT system. 200x1024x1024 matrix data of micro-CT is obtained with the magnification of 1.77 and pixel size of 31x31μm². In our reconstruction software, output image size of micro-CT slices data, magnification factor and rotation sample degree can be modified in the condition of different computational efficiency and reconstruction region. The reconstructed image matrix data is processed and visualization by Visualization Toolkit (VTK). Data parallelism of VTK is performed in surface rendering of reconstructed data in order to improve computing speed. Computing time of processing a 512x512x512 matrix datasets is about 1/20 compared with serial program when 30 CPU is used. The voxel size is 54x54x108 μm³. The reconstruction and 3-D visualization images of laboratory rat ear are presented.

Citation Download Citation

Hui Gong, Qian Liu, Aijun Zhong, Shan Ju, Quan Fang, and Zheng Fang "Micro-CT images reconstruction and 3D visualization for small animal studying", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.580577

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KEYWORDS

Reconstruction algorithms

Charge-coupled devices

Sensors

Visualization

3D image processing

X-rays

CCD image sensors

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