Technology and mechanism of neuron inactivation by N<sub>2</sub> laser radiation (&#955;=337 nm), mercury-vapor lamp (Hg &#955;=365 nm), and low-coherence UV-A sun radiation

Garif G. Akchurin; George G. Akchurin; George A. Seliverstov; Artyom Yu. Trofimov

doi:10.1117/12.589306

25 April 2005 Technology and mechanism of neuron inactivation by N₂ laser radiation (λ=337 nm), mercury-vapor lamp (Hg λ=365 nm), and low-coherence UV-A sun radiation

Garif G. Akchurin, George G. Akchurin, George A. Seliverstov, Artyom Yu. Trofimov

Author Affiliations +

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.589306
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The method of the local functional injury of somatic frog's nerve using high coherent UV-A radiation of N₂ laser (λ=337nm, P~10 mW), coherent mercury-vapor lamp radiation (λ=365; 312 nm P_Σ~2 mW/cm²) and low-coherence UV-A sun radiation (400-315 nm, PΣ~10 mW) was realized. The level of injury was assessed from the decrease of compound action potential of the nerve stimulated extracellularly by electrical pulses of millisecond duration. Study of dynamic response of the bundle of axons revealed the decrease of the number of action potential which can be generated (less than 10⁵). This decrease may be attributed to destruction of action transport and/or voltage-activated ion channels of axon membrane. The dose dependence of the level of nerve injury was studied using varied both intensity and duration of high and low-coherent UV-A irradiation.

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Garif G. Akchurin, George G. Akchurin, George A. Seliverstov, and Artyom Yu. Trofimov "Technology and mechanism of neuron inactivation by N₂ laser radiation (λ=337 nm), mercury-vapor lamp (Hg λ=365 nm), and low-coherence UV-A sun radiation", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.589306

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