Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography

A. D. Aguirre; Y. Chen; L. Ruvinskaya; A. Devor; D. A. Boas; J. G. Fujimoto

doi:10.1117/12.641798

7 October 2005 Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography

A. D. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D. A. Boas, J. G. Fujimoto

Author Affiliations +

Proceedings Volume 5861, Optical Coherence Tomography and Coherence Techniques II; 58611D (2005) https://doi.org/10.1117/12.641798
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Simultaneous optical coherence tomography (OCT) and video microscopy were performed on the rat somatosensory cortex through a thinned skull during forepaw stimulation. Fractional change measurements in OCT images reveal a functional signal timecourse similar to well understood hemodynamic signal timecourses measured with video microscopy. The precise etiology of the observed OCT functional signal is still under investigation, but these results suggest that OCT can provide high-resolution cross-sectional images of functional neuro-vascular activation.

Citation Download Citation

A. D. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D. A. Boas, and J. G. Fujimoto "Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography", Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58611D (7 October 2005); https://doi.org/10.1117/12.641798

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