Photodynamic therapy for implanted VX2 tumor in rabbit brains

Fei Li; Hua Feng; Jiangkai Lin; Gang Zhu; Zhi Chen; Cong-yan Li

doi:10.1117/12.639236

11 September 2006 Photodynamic therapy for implanted VX2 tumor in rabbit brains

Fei Li, Hua Feng, Jiangkai Lin, Gang Zhu, Zhi Chen, Cong-yan Li

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596711 (2006) https://doi.org/10.1117/12.639236
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

To evaluate the therapeutic effect and the safety of single photodynamic therapy (PDT) with hematoporphyrin derivative produced in China, 60 New Zealand adult rabbits with VX2 tumor implanted into the brain were divided randomly into non-PDT-group and PDT-group. 36 rabbits of the PDT-group were performed photodynamic therapy. The survival time, neurological deteriorations, intracranial pressure (ICP), histology, pathology, tumor volume and brain water content were measured. Other 12 rabbits were received hematoporphyrin derivative and light irradiation of the normal brain. The ICP, histology, pathology, and brain water content were measured. The result indicated that Simple PDT may elongate the average survival time of the rabbits with VX2 tumors significantly; kill tumor cells; cause transient brain edema and increase ICP, but it is safe to be used in treating brain tumor.

Citation Download Citation

Fei Li, Hua Feng, Jiangkai Lin, Gang Zhu, Zhi Chen, and Cong-yan Li "Photodynamic therapy for implanted VX2 tumor in rabbit brains", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596711 (11 September 2006); https://doi.org/10.1117/12.639236

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