Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment

Yichao Chen; Surya C. Gnyawali; Feng Wu; Hong Liu; Yasvir A. Tesiram; Andrew Abbott; Rheal A. Towner; Wei R. Chen

doi:10.1117/12.698014

13 February 2007 Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment

Yichao Chen, Surya C. Gnyawali, Feng Wu, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, Wei R. Chen

Proceedings Volume 6438, Biophotonics and Immune Responses II; 64380C (2007) https://doi.org/10.1117/12.698014
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

In cancer treatment and immune response enhancement research, Magnetic Resonance Imaging (MRI) is an ideal method for non-invasive, three-dimensional temperature measurement. We used a 7.1-Tesla magnetic resonance imager for ex vivo tissues and small animal to determine temperature distribution of target tissue during laser irradiation. The feasibility of imaging is approved with high spatial resolution and high signal-noise- ratio. Tissue-simulating gel phantom gel, biological tissues, and tumor-bearing animals were used in the experiments for laser treatment and MR imaging. Thermal couple measurement of temperature in target samples was used for system calibration. An 805-nm laser was used to irradiate the samples with a laser power in the range of 1 to 2.5 watts. Using the MRI system and a specially developed processing algorithm, a clear temperature distribution matrix in the target tissue and surrounding tissue was obtained. The temperature profiles show that the selective laser photothermal effect could result in tissue temperature elevation in a range of 10 to 45 °C. The temperature resolution of the measurement was about 0.37°C including the total system error. The spatial resolution was 0.4 mm (128x128 pixels with field of view of 5.5x5.5 cm). The temperature distribution provided in vivo thermal information and future reference for optimizing dye concentration and irradiation parameters to achieve optimal thermal effects in cancer treatment.

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Yichao Chen, Surya C. Gnyawali, Feng Wu, Hong Liu, Yasvir A. Tesiram, Andrew Abbott, Rheal A. Towner, and Wei R. Chen "Tissue temperature distribution measurement by MRI and laser immunology for cancer treatment", Proc. SPIE 6438, Biophotonics and Immune Responses II, 64380C (13 February 2007); https://doi.org/10.1117/12.698014

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KEYWORDS

Magnetic resonance imaging

Temperature metrology

Tumors

Tissues

Magnetism

Laser tissue interaction

Laser irradiation

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