Time-resolved fluorescence tomography in cancer research: backward versus toward geometry

Laurent Guyon; Lionel Hervé; Jérome Boutet; Mathieu Debourdeau; Nadia Djaker; Anabela da Silva; Philippe Peltié; Jean-Marc Dinten; Philippe Rizo

doi:10.1117/12.808237

12 February 2009 Time-resolved fluorescence tomography in cancer research: backward versus toward geometry

Laurent Guyon, Lionel Hervé, Jérome Boutet, Mathieu Debourdeau, Nadia Djaker, Anabela da Silva, Philippe Peltié, Jean-Marc Dinten, Philippe Rizo

Author Affiliations +

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71741X (2009) https://doi.org/10.1117/12.808237
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Fluorescence Diffuse Optical Tomography is an optical non-invasive molecular technique for cancer imaging. Depending on the accessibility of the organ two main geometries might be considered, reflection or transmission. We will present first experimental and reconstruction comparison between these two geometries, on a laboratory time resolved bench. Both acquisitions were made using a fluorophore inclusion positioned in a liquid phantom, with breast comparable optical properties. We successfully reconstructed all fluorophore positions examined in both geometries. Reflection geometry suffers of many drawbacks that we have to deal with. We will present all challenges it implies, and also what are the advantages to use time resolved techniques in both geometries.

Citation Download Citation

Laurent Guyon, Lionel Hervé, Jérome Boutet, Mathieu Debourdeau, Nadia Djaker, Anabela da Silva, Philippe Peltié, Jean-Marc Dinten, and Philippe Rizo "Time-resolved fluorescence tomography in cancer research: backward versus toward geometry", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741X (12 February 2009); https://doi.org/10.1117/12.808237

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