A high-sensitive diffuse fluorescence tomography system with CT-analogous scanning mode

Xin Wang; Jiao Li; Xi Yi; Linhui Wu; Wenjuan Ma; Wei Zhang; Feng Gao

doi:10.1117/12.905355

29 February 2012 A high-sensitive diffuse fluorescence tomography system with CT-analogous scanning mode

Xin Wang, Jiao Li, Xi Yi, Linhui Wu, Wenjuan Ma, Wei Zhang, Feng Gao

Proceedings Volume 8216, Multimodal Biomedical Imaging VII; 82160V (2012) https://doi.org/10.1117/12.905355
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Diffuse fluorescence tomography (DFT) provides spatial distributions of fluorescence parameters by measuring fluorescence signals of probes or agents that are targeted to interior specific molecules or tissues. The potential applications of DFT can be found in drug development and early tumor diagnosis. This work proposes a CT-analogous mode of DFT, where the imaging chamber is impinged by collimated beam from a fiber-coupled laser diode and the resultant fluorescence re-emissions on the opposite side, i.e., the so-called "projections", are collected by eight detection fibers placed from 101.25º to 258.75º perspectives opposite to the incidence that are then successively filtered out into a photon-counting channel for quantification. By rotating the imaging chamber or phantom at an angular, the system acquires the "projections" of surface-emitted fluorescence under different perspectives as a CT system does. This ease of acquiring a large data-set enables realization of high-quality imaging. Pilot experiments on phantoms with Cy5.5-target embedded have validated the efficacy of the proposed method.

Citation Download Citation

Xin Wang, Jiao Li, Xi Yi, Linhui Wu, Wenjuan Ma, Wei Zhang, and Feng Gao "A high-sensitive diffuse fluorescence tomography system with CT-analogous scanning mode", Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160V (29 February 2012); https://doi.org/10.1117/12.905355

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available