Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study

Zhifang Li; Yubing Liu; Hui Li; Wei R. Chen; Haiyu Chen; Huan Wang

doi:10.1117/12.2001756

22 February 2013 Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study

Zhifang Li, Yubing Liu, Hui Li, Wei R. Chen, Haiyu Chen, Huan Wang

Author Affiliations +

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 858209 (2013) https://doi.org/10.1117/12.2001756
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this study, we proposed photoacoustic imaging to monitor the temperature increase during photothermal therapy, which was carried out by utilizing a continuous wave laser and photoabsorber-enhanced black ink with a absorption peak in the near-infrared optical range. A focusing photoacoustic imaging is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms before and after laser irradiation. The results demonstrated that changes in the photoacoustic signal could reflect temperature changes in tissue. More importantly, photoacoustic signal could be used to determine the temperature at the boundary of photoabsorber-enhance tissue during photothermal irradiation. Thus, the photoacoustic imaging could potentially become an effective tool to guide photoabsorber-enhanced photothermal therapy.

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Zhifang Li, Yubing Liu, Hui Li, Wei R. Chen, Haiyu Chen, and Huan Wang "Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 858209 (22 February 2013); https://doi.org/10.1117/12.2001756

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KEYWORDS

Photoacoustic imaging

Photoacoustic spectroscopy

Tissue optics

Laser irradiation

Temperature metrology

Cancer

Laser therapeutics

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