Inhibitory efficacy of the quantified prunellae spica extract on H22 tumor bearing mice

Zhi-ping Wang; Tong-sheng Chen

doi:10.1117/12.2002844

22 February 2013 Inhibitory efficacy of the quantified prunellae spica extract on H22 tumor bearing mice

Zhi-ping Wang, Tong-sheng Chen

Proceedings Volume 8582, Biophotonics and Immune Responses VIII; 85820S (2013) https://doi.org/10.1117/12.2002844
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistence of the advanced hepatocarcinoma to chemotherapy. In this report, we assessed the antitumor activity of a prunellae spica aqueous extract (PSE) in vitro and in vivo. PSE was quantified by HPLC and UV. MTT assay showed that PSE did not effectively inhibit the growth of H22 cells. The in vivo anti-tumor activity was assessed by using the mice bearing H22 tumor. In vivo studies showed the higher antitumor efficacy of PSE without significant side effect assessed by the reduced tumor weight, and the extended survival time of the mice bearing H22 solid and ascites tumor. Collectively, PSE is a promising Chinese medicinal herb for treating hepatocarcinoma.

Citation Download Citation

Zhi-ping Wang and Tong-sheng Chen "Inhibitory efficacy of the quantified prunellae spica extract on H22 tumor bearing mice", Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820S (22 February 2013); https://doi.org/10.1117/12.2002844

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