Fast drug screening platform for cancer treatment based on live tissue culturing and high-speed 3D imaging

Qiuyuan Zhong; Chen-Yuan Dong; Xinlei Fu; Xiayi Xu; Shih-Chi Chen

doi:10.1117/12.2609938

28 April 2022 Fast drug screening platform for cancer treatment based on live tissue culturing and high-speed 3D imaging

Qiuyuan Zhong, Chen-Yuan Dong, Xinlei Fu, Xiayi Xu, Shih-Chi Chen

Author Affiliations +

Proceedings Volume PC11946, Neural Imaging and Sensing 2022; PC119460K (2022) https://doi.org/10.1117/12.2609938
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Fast and accurate drug screening can significantly improve the survival rate of cancer patients. Here, we present a new drug screening platform for cancer treatment based on an integrated precision microtome and LiMo microscope. Through this platform, tumor specimens from patients are first sectioned into 100-micron thick tissue slices and cultured for a few days; next, the live tumor tissue array is tested with different anti-cancer drugs for a few weeks and regularly 3D imaged at subcellular resolution, realizing personalized medicine. Our preliminary study on human oral cancer tissue has confirmed the feasibility of the drug screening platform.

Conference Presentation

Citation Download Citation

Qiuyuan Zhong, Chen-Yuan Dong, Xinlei Fu, Xiayi Xu, and Shih-Chi Chen "Fast drug screening platform for cancer treatment based on live tissue culturing and high-speed 3D imaging", Proc. SPIE PC11946, Neural Imaging and Sensing 2022, PC119460K (28 April 2022); https://doi.org/10.1117/12.2609938

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