Validation of the Cherenkov converted dose using multiple Cherenkov images on TSET patients

Yifeng Zhu; Brook Byrd; Daniel Alexander; Amit Maity; John P. Plastaras; Michael LaRiviere; Brian W. Pogue; Timothy C. Zhu

doi:10.1117/12.3003498

13 March 2024 Validation of the Cherenkov converted dose using multiple Cherenkov images on TSET patients

Yifeng Zhu, Brook Byrd, Daniel Alexander, Amit Maity, John P. Plastaras, Michael LaRiviere, Brian W. Pogue, Timothy C. Zhu

Author Affiliations +

Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC1282302 (2024) https://doi.org/10.1117/12.3003498
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Cherenkov imaging provides a valuable tool for the quality assurance of dose homogeneity in total skin electron therapy (TSET), in which patients were treated in six different postures using the Stanford standing technique. The emitted Cherenkov signals can be captured by three Cherenkov cameras, converted to 2D dose maps after certain corrections, and projected onto the patient specific 3D model to evaluate the cumulative total skin dose distribution. This study aims to improve the accuracy and reliability of Cherenkov converted dose obtained from the combination of multi-view Cherenkov images. The extra correction factors are investigated by conducting manikin phantom experiments as well as GAMOS based Monte Carlo simulations, and validated with in vivo dosimetry (IVD). We have also calibrated the side cameras and achieved a straightforward conversion of all Cherenkov images into doses using only the front camera. We have improved the Cherenkov-to-dose correction and conversion method, significantly reducing the deviation between the Cherenkov-converted dose and IVD measurements.

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Citation Download Citation

Yifeng Zhu, Brook Byrd, Daniel Alexander, Amit Maity, John P. Plastaras, Michael LaRiviere, Brian W. Pogue, and Timothy C. Zhu "Validation of the Cherenkov converted dose using multiple Cherenkov images on TSET patients", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC1282302 (13 March 2024); https://doi.org/10.1117/12.3003498

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KEYWORDS

Cameras

3D modeling

Monte Carlo methods

Skin

Calibration

Dosimetry

In vivo imaging

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